Evidence map›Paper›PMID 30292301›Full record

ArticleAnalytica chimica acta2018

Utilizing ion mobility spectrometry and mass spectrometry for the analysis of polycyclic aromatic hydrocarbons, polychlorinated biphenyls, polybrominated diphenyl ethers and their metabolites.

Xueyun Zheng, Kevin T Dupuis, Noor A Aly, Yuxuan Zhou, Francesca B Smith, Keqi Tang, Richard D Smith, Erin S Baker

Abstract read
In one paragraph

Article in Analytica chimica acta, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

  1. Article
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  5. Mass Spectrometry Imaging for Spatial Toxicology Research.Journal of mass spectrometry : JMS · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xueyun ZhengBiological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, United States.
Kevin T DupuisBiological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, United States.
Noor A AlyBiological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, United States.
Yuxuan ZhouBiological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, United States.
Francesca B SmithBiological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, United States.
Keqi TangBiological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, United States.
Richard D SmithBiological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, United States.
Erin S BakerBiological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, United States. Electronic address: erin.baker@pnnl.gov.

Funding

Equipment Supplement Request for a Research Resource for Ultra-sensitive High Throughput ProteomicsP41GM103493 · NIGMS · BATTELLE PACIFIC NORTHWEST LABORATORIES · PI SMITH, RICHARD D · 2012 to 2022
$22.6M
Single cell, multi-parametric high throughput platform to classify endocrine disruptor potential of mixturesP42ES027704 · NIEHS · TEXAS A&M UNIVERSITY · PI Weihsueh A Chiu · 2017 to 2026
$21.2M
Regulatory Science in Environmental Health and ToxicologyT32ES026568 · NIEHS · TEXAS A&M UNIVERSITY · PI Weihsueh A Chiu, Natalie M Johnson · 2016 to 2026
$3.8M
Platform Providing Increased Throughput, Sensitivity and Specificity for MetaboloR01ES022190 · NIEHS · BATTELLE PACIFIC NORTHWEST LABORATORIES · PI BAKER, ERIN S · 2012 to 2016
$2.2M
NIEHS NIH HHS P42 ES027704NIEHS NIH HHS R01 ES022190NIEHS NIH HHS T32 ES026568NIGMS NIH HHS P41 GM103493
6 · The paper itself

Abstract

Polycyclic aromatic hydrocarbons (PAHs), polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs) are persistent environmental pollutants originating from incomplete combustion of organic materials and synthetic sources. PAHs, PCBs, and PBDEs have all been shown to have a significant effect on human health with correlations to cancer and other diseases. Therefore, measuring the presence of these xenobiotics in the environment and human body is imperative for assessing their health risks. To date, their analyses require both gas chromatography and liquid chromatography separations in conjunction with mass spectrometry measurements for detection of both the parent molecules and their hydroxylated metabolites, making their studies extremely time consuming. In this work, we characterized PAHs, PCBs, PBDEs and their hydroxylated metabolites using ion mobility spectrometry coupled with mass spectrometry (IMS-MS) and in combination with different ionization methods including electrospray ionization (ESI), atmospheric pressure chemical ionization (APCI) and atmospheric pressure photoionization (APPI). The collision cross section and m/z trend lines derived from the IMS-MS analyses displayed distinct trends for each molecule type. Additionally, the rapid isomeric and molecular separations possible with IMS-MS showed great promise for quickly distinguishing the parent and metabolized PAH, PCB, and PDBE molecules in complex environmental and biological samples.

Indexed as

Chromatography, LiquidHalogenated Diphenyl EthersIon Mobility SpectrometryMass SpectrometryMolecular StructurePolybrominated BiphenylsPolycyclic Aromatic HydrocarbonsHalogenated Diphenyl EthersPolybrominated BiphenylsPolycyclic Aromatic HydrocarbonsAtmospheric pressure chemical ionizationAtmospheric pressure photoionizationCollision cross sectionElectrospray ionizationIon mobility spectrometryPolybrominated diphenyl ethersPolychlorinated biphenylsPolycyclic aromatic hydrocarbonsXenobiotics

Identifiers

PMID30292301
PMCPMC6223027

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.