ArticleNeuroImage2019
Gustatory responses in macaque monkeys revealed with fMRI: Comments on taste, taste preference, and internal state.
Article in NeuroImage, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 27 citations in OpenAlex.
- Comparative insights into insula structure and function.Nature neuroscience · 2026Review
- Association of simultaneous sour taste stimulation with prefrontal cortex activation during stroop task performance in healthy adults: a fNIRS study.Frontiers in behavioral neuroscience · 2026Article
- Preferences for fat, sugar, and oral-sensory food qualities in monkeys and humans.Physiology & behavior · 2025Review
- The Isle of Craig: Neuroanatomical and Functional Evidence for a Role of the Insular Cortex in Subjective Feelings.Current topics in behavioral neurosciences · 2025Review
- The macaque ventral intraparietal functional connectivity patterns reveal an anterio-posterior specialization mirroring that described in human ventral intraparietal area.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- A Matter of Taste: Roles of Taste Preference on Performance and Psychological Responses during Anaerobic Exercise.International journal of environmental research and public health · 2023Article
- Intrinsic functional clustering of the macaque insular cortex.Frontiers in integrative neuroscience · 2023Article
- Association of increased abdominal adiposity at birth with altered ventral caudate microstructure.International journal of obesity (2005) · 2021Article
- Effective Connectivity in the Human Brain for Sour Taste, Retronasal Smell, and Combined Flavour.Foods (Basel, Switzerland) · 2021Article
- Preferences for nutrients and sensory food qualities identify biological sources of economic values in monkeys.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Metaplasticity in the Ventral Pallidum as a Potential Marker for the Propensity to Gain Weight in Chronic High-Calorie Diet.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Reward activity in ventral pallidum tracks satiety-sensitive preference and drives choice behavior.Science advances · 2020Article
- Global reward state affects learning and activity in raphe nucleus and anterior insula in monkeys.Nature communications · 2020Article
- Identification of an Amygdala-Thalamic Circuit That Acts as a Central Gain Mechanism in Taste Perceptions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Rapid event-related, BOLD fMRI, non-human primates (NHP): choose two out of three.Scientific reports · 2020Article
- Taste Quality Representation in the Human Brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Statistical Learning Signals for Complex Visual Images in Macaque Early Visual Cortex.Frontiers in neuroscience · 2020Article
- Open-Source Joystick Manipulandum for Decision-Making, Reaching, and Motor Control Studies in Mice.eNeuroArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Studies of the neural mechanisms underlying value-based decision making typically employ food or fluid rewards to motivate subjects to perform cognitive tasks. Rewards are often treated as interchangeable, but it is well known that the specific tastes of foods and fluids and the values associated with their taste sensations influence choices and contribute to overall levels of food consumption. Accordingly, we characterized the gustatory system in three macaque monkeys (Macaca mulatta) and examined whether gustatory responses were modulated by preferences and hydration status. To identify taste-responsive cortex, we delivered small quantities (0.1 ml) of sucrose (sweet), citric acid (sour), or distilled water in random order without any predictive cues while scanning monkeys using event-related fMRI. Neural effects were evaluated by using each session in each monkey as a data point in a second-level analysis. By contrasting BOLD responses to sweet and sour tastes with those from distilled water in a group level analysis, we identified taste responses in primary gustatory cortex area G, an adjacent portion of the anterior insular cortex, and prefrontal cortex area 12o. Choice tests administered outside the scanner revealed that all three monkeys strongly preferred sucrose to citric acid or water. BOLD responses in the ventral striatum, ventral pallidum, and amygdala reflected monkeys' preferences, with greater BOLD responses to sucrose than citric acid. Finally, we examined the influence of hydration level by contrasting BOLD responses to receipt of fluids when monkeys were thirsty and after ad libitum water consumption. BOLD responses in area G and area 12o in the left hemisphere were greater following full hydration. By contrast, BOLD responses in portions of medial frontal cortex were reduced after ad libitum water consumption. These findings highlight brain regions involved in representing taste, taste preference and internal state.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.