Evidence map›Paper›PMID 30291962›Full record

ArticleBiochimica et biophysica acta. Molecular and cell biology of lipids2019

A 5‑lipoxygenase-specific sequence motif impedes enzyme activity and confers dependence on a partner protein.

Erin E Schexnaydre, Jana Gerstmeier, Ulrike Garscha, Paul M Jordan, Oliver Werz, Marcia E Newcomer

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochimica et biophysica acta. Molecular and cell biology of lipids, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Drug design, development and therapy · 2025
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Erin E SchexnaydreDepartment of Biological Sciences, Louisiana State University, Baton Rouge, LA, USA.
Jana GerstmeierPharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich-Schiller-University Jena, 07743 Jena, Germany.
Ulrike GarschaPharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich-Schiller-University Jena, 07743 Jena, Germany.
Paul M JordanPharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich-Schiller-University Jena, 07743 Jena, Germany.
Oliver WerzPharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich-Schiller-University Jena, 07743 Jena, Germany.
Marcia E NewcomerDepartment of Biological Sciences, Louisiana State University, Baton Rouge, LA, USA. Electronic address: newcomer@lsu.edu.
Friedrich Schiller University Jena · DELouisiana State University · US

Funding

The Structural Basis for Control of 5-Lipoxgenease ActivityR01HL107887 · NHLBI · LOUISIANA STATE UNIV A&M COL BATON ROUGE · PI NEWCOMER, MARCIA E. · 2011 to 2014
$1.4M
NHLBI NIH HHS R01 HL107887
6 · The paper itself

Abstract

Leukotrienes (LT) are lipid mediators of the inflammatory response that play key roles in diseases such as asthma and atherosclerosis. The precursor leukotriene A

Indexed as

5-Lipoxygenase-Activating ProteinsAmino Acid MotifsArachidonate 5-LipoxygenaseArachidonic AcidBinding SitesHEK293 CellsHumansLeukotriene A4Models, MolecularMutationProtein Binding5-Lipoxygenase-Activating ProteinsALOX5AP protein, humanALOX5 protein, humanArachidonate 5-LipoxygenaseArachidonic AcidLeukotriene A4Arachidonic acidEicosanoidsEnzyme regulationFLAPLeukotriene A(4)Lipoxygenase

Identifiers

PMID30291962
PMCPMC6369011
OpenAlexW2894940110

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.