Evidence map›Paper›PMID 30291886›Full record

ArticleBiochimica et biophysica acta. Molecular basis of disease2018

Biglycan gene connects metabolic dysfunction with brain disorder.

Zhe Ying, Hyae Ran Byun, Qingying Meng, Emily Noble, Guanglin Zhang, Xia Yang, Fernando Gomez-Pinilla

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochimica et biophysica acta. Molecular basis of disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Zhe YingDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, California 90095, USA.
Hyae Ran ByunDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, California 90095, USA.
Qingying MengDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, California 90095, USA.
Emily NobleDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, California 90095, USA.
Guanglin ZhangDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, California 90095, USA.
Xia YangDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, California 90095, USA. Electronic address: xyang123@ucla.edu.
Fernando Gomez-PinillaDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, California 90095, USA; Department of Neurosurgery, UCLA Brain Injury Research Center, University of California, Los Angeles, Los Angeles, California 90095, USA. Electronic address: fgomezpi@ucla.edu.
University of California, Los Angeles · US

Funding

Restoration of Homeostasis After Brain TraumaR01NS050465 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GOMEZ-PINILLA, FERNANDO · 2005 to 2019
$5.5M
DHA Reverses Gene Network Signatures of Fructose-induced Metabolic SyndromeR01DK104363 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI YANG, XIA · 2015 to 2019
$2.4M
Cell-specific novel genomic biomarkers of TBI pathologyR21NS103088 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GOMEZ-PINILLA, FERNANDO, YANG, XIA · 2017 to 2018
$406k
NIDDK NIH HHS R01 DK104363NINDS NIH HHS R01 NS050465NINDS NIH HHS R21 NS103088
6 · The paper itself

Abstract

Dietary fructose is a major contributor to the epidemic of diabetes and obesity, and it is an excellent model to study metabolic syndrome. Based on previous studies that Bgn gene occupies a central position in a network of genes in the brain in response to fructose consumption, we assessed the capacity of Bgn to modulate the action of fructose on brain and body. We exposed male biglycan knockout mice (Bgn

Indexed as

Metabolic Networks and PathwaysAnimalsBiglycanBody CompositionBrain DiseasesCells, CulturedCyclic AMP Response Element-Binding ProteinFructoseGene Expression ProfilingGlucoseGlucose IntoleranceLipid MetabolismLiverMaleMaze LearningMice, KnockoutBiglycanCreb1 protein, mouseCyclic AMP Response Element-Binding ProteinFructoseGlucoseCognitionHippocampusHypothalamusLiverMetabolismTranscriptome

Identifiers

PMID30291886
PMCPMC6239930
OpenAlexW2895690637

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.