Evidence map›Paper›PMID 30291854›Full record

ReviewExperimental neurology2019

Matrices, scaffolds & carriers for cell delivery in nerve regeneration.

Ze Zhong Wang, Shelly E Sakiyama-Elbert

Open access · greenAbstract readReview
In one paragraph

Review in Experimental neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 79 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Peripheral nerve repair: innovations and future directions.Journal of translational medicine · 2026
    Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Ze Zhong WangDepartment of Biomedical Engineering, Washington University in St. Louis, St. Louis, Missouri, USA; Department of Biomedical Engineering, University of Austin at Texas, Austin, TX, USA.
Shelly E Sakiyama-ElbertDepartment of Biomedical Engineering, University of Austin at Texas, Austin, TX, USA. Electronic address: sakiyama@utexas.edu.
The University of Texas at Austin · USWashington University in St. Louis · US

Funding

THE EFFECTS OF GDNF ON PERIPHERAL NERVE REGENERATIONR01NS051706 · NINDS · WASHINGTON UNIVERSITY · PI MACKINNON, SUSAN E, SAKIYAMA-ELBERT, SHELLY ELESE · 2006 to 2016
$4.0M
NINDS NIH HHS R01 NS051706
6 · The paper itself

Abstract

Nerve injuries can be life-long debilitating traumas that severely impact patients' quality of life. While many acellular neural scaffolds have been developed to aid the process of nerve regeneration, complete functional recovery is still very difficult to achieve, especially for long-gap peripheral nerve injury and most cases of spinal cord injury. Cell-based therapies have shown many promising results for improving nerve regeneration. With recent advances in neural tissue engineering, the integration of biomaterial scaffolds and cell transplantation are emerging as a more promising approach to enhance nerve regeneration. This review provides an overview of important considerations for designing cell-carrier biomaterial scaffolds. It also discusses current biomaterials used for scaffolds that provide permissive and instructive microenvironments for improved cell transplantation.

Indexed as

Nerve RegenerationTissue ScaffoldsAnimalsDrug CarriersHumansPeripheral Nerve InjuriesStem Cell TransplantationTissue EngineeringDrug CarriersBiomaterialsCell-carriersExtracellular matrixInduced pluripotent stem cellsNerve repairNeural stem cellsOlfactory ensheathing cellsPeripheral nerve injurySchwann cellsSpinal cord injury

Identifiers

PMID30291854
PMCPMC6447476
OpenAlexW2894629316

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.