ArticleThe Journal of allergy and clinical immunology2019
Epidemiology and risk factors of asthma-chronic obstructive pulmonary disease overlap in low- and middle-income countries.
Article in The Journal of allergy and clinical immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- Global prevalence of asthma-COPD overlap (ACO) in the general population: a systematic review and meta-analysis.Respiratory research · 2019Pooled it
- Trial
- Dupilumab in Severe Asthma-COPD Overlap: Real-Life Experience on a Case Series.Journal of personalized medicine · 2026Article
- Multifaceted mechanistic exploration ofFrontiers in cell and developmental biology · 2026Article
- Genome-wide Association Study IdentifiesAllergy, asthma & immunology research · 2026Article
- Insights into household air pollution: A systematic scoping review on perceptions of solid biomass fuel use in South Asian countries.Journal of family medicine and primary care · 2025Review
- Established and Emerging Biological Therapies for the Treatment of Comorbid Asthma and Chronic Obstructive Pulmonary Disease.Journal of inflammation research · 2025Review
- Effectiveness of ICS/LABA and LAMA/LABA in COPD due to biomass.ERJ open research · 2024Article
- Clinical Characteristics of T2-Low and T2-High Asthma-Chronic Obstructive Pulmonary Disease Overlap: Findings From COREA Cohort.Allergy, asthma & immunology research · 2024Article
- Enhancing pediatric asthma management through multifaceted health education.World journal of clinical cases · 2024Article
- "Air That Once Was Breath" Part 1: Wildfire-Smoke-Induced Mechanisms of Airway Inflammation - "Climate Change, Allergy and Immunology" Special IAAI Article Collection: Collegium Internationale Allergologicum Update 2023.International archives of allergy and immunology · 2024Review
- Prevalence and Associated Factors of Chronic Obstructive Pulmonary Disease Among Adults in Neno District, Malawi: A Cross-Sectional Analytical Study.International journal of chronic obstructive pulmonary disease · 2024Article
- A systematic exploration of ginsenoside Rg5 reveals anti-inflammatory functions in airway mucosa cells.Journal of ginseng research · 2023Article
- A Proposal to Differentiate ACO, Asthma and COPD in Vietnam.Journal of personalized medicine · 2022Article
- Influence of Rural Environmental Factors in Asthma.Immunology and allergy clinics of North America · 2022Review
- Pathophysiology of Asthma-Chronic Obstructive Pulmonary Disease Overlap.Immunology and allergy clinics of North America · 2022Review
- Availability, affordability and access to essential medications for asthma and chronic obstructive pulmonary disease in three low- and middle-income country settings.PLOS global public health · 2022Article
- Short-term exposure to ozone and asthma exacerbation in adults: A longitudinal study in China.Frontiers in public health · 2022Article
- Rationale and design of the Early Chronic Obstructive Pulmonary Disease (ECOPD) study in Guangdong, China: a prospective observational cohort study.Journal of thoracic disease · 2021Article
- The coexistence of asthma and COPD: risk factors, clinical history and lung function trajectories.The European respiratory journal · 2021Article
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Authors and funding
12 authors at 6 institutions in 5 countries.
Funding
Abstract
backgroundAsthma-chronic obstructive pulmonary disease (COPD) overlap (ACO) represents the confluence of bronchial airway hyperreactivity and chronic airflow limitation and has been described as leading to worse lung function and quality of life than found with either singular disease process.
objectiveWe aimed to describe the prevalence and risk factors for ACO among adults across 6 low- and middle-income countries (LMICs).
methodsWe compiled cross-sectional data for 11,923 participants aged 35 to 92 years from 4 population-based studies in 12 settings. We defined COPD as postbronchodilator FEV
resultsThe prevalence of ACO was 3.8% (0% in rural Puno, Peru, to 7.8% in Matlab, Bangladesh). The odds of having ACO were higher with household exposure to biomass fuel smoke (odds ratio [OR], 1.48; 95% CI, 0.98-2.23), smoking tobacco (OR, 1.28 per 10 pack-years; 95% CI, 1.22-1.34), and having primary or less education (OR, 1.35; 95% CI, 1.07-1.70) as compared to nonobstructed nonasthma individuals. ACO was associated with severe obstruction (FEV
conclusionsACO may be as prevalent and more severe in LMICs than has been reported in high-income settings. Exposure to biomass fuel smoke may be an overlooked risk factor, and we favor diagnostic criteria for ACO that include environmental exposures common to LMICs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.