Evidence map›Paper›PMID 30291564›Full record

ArticleJournal of neurovirology2018

Genetic characterization of measles virus genotype D6 subacute sclerosing panencephalitis case, Alberta, Canada.

K Pabbaraju, K Fonseca, S Wong, M W Koch, J T Joseph, G A Tipples, R Tellier

Abstract readCase Reports
PubMed Publisher
In one paragraph

Article in Journal of neurovirology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

K PabbarajuProvincial Laboratory for Public Health, Calgary, Alberta, Canada. kanti.pabbaraju@albertahealthservices.ca.
K FonsecaProvincial Laboratory for Public Health, Calgary, Alberta, Canada.
S WongProvincial Laboratory for Public Health, Calgary, Alberta, Canada.
M W KochDepartments of Clinical Neurosciences and Community Health Sciences, University of Calgary, Calgary, Alberta, Canada.
J T JosephDepartment of Pathology and Laboratory Medicine, University of Calgary, Calgary, Alberta, Canada.
G A TipplesDepartment of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta, Canada.
R TellierProvincial Laboratory for Public Health, Calgary, Alberta, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Subacute sclerosing panencephalitis (SSPE) is a progressive and eventually fatal neurological disease arising from a persistent infection with measles virus (MV) acquired at a young age. SSPE measles virus strains are defective and unable to produce progeny virions, due to multiple and extensive mutations in a number of key genes. We sequenced the full MV genome from our recently reported SSPE case, which typed as genotype D6, and compared it with other genotype D6 wild type and SSPE sequences. The Alberta D6 strain was significantly different from other reported SSPE D6 sequences. Mutations were observed in all the genes of the Alberta strain, with the greatest sequence divergence noted in the M gene with 17.6% nucleotide and 31% amino acid variation. The L gene showed the least variation with 1.3% nucleotide and 0.7% amino acid differences respectively. The nucleotide variability for 15,672 bases of the complete genome compared to the wild type and other SSPE D6 strains was around 3%.

Indexed as

AdultAlbertaFemaleGenes, ViralGenotypeHumansPregnancyPregnancy Complications, InfectiousSSPE VirusSubacute Sclerosing PanencephalitisBiased hypermutationGenotype D6Measles virusSSPE

Identifiers

PMID30291564

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.