Evidence map›Paper›PMID 30291470›Full record

ArticleClinical rheumatology2018

Dickkopf-1 (Dkk-1) serum levels in systemic sclerosis and rheumatoid arthritis patients: correlation with the Trabecular Bone Score (TBS).

Barbara Ruaro, Andrea Casabella, Sabrina Paolino, Carmen Pizzorni, Massimo Ghio, Chiara Seriolo, Luigi Molfetta, Patrizio Odetti, Vanessa Smith, Maurizio Cutolo

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In one paragraph

Article in Clinical rheumatology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  17. Trabecular Bone Score in Rheumatic Disease.Current rheumatology reports · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Barbara RuaroResearch Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine (Di.M.I.), Polyclinic San Martino Hospital, University of Genova, Viale Benedetto XV, no. 6, 16132, Genoa, Italy. barbara.ruaro@yahoo.it.
Andrea CasabellaResearch Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine (Di.M.I.), Polyclinic San Martino Hospital, University of Genova, Viale Benedetto XV, no. 6, 16132, Genoa, Italy.
Sabrina PaolinoResearch Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine (Di.M.I.), Polyclinic San Martino Hospital, University of Genova, Viale Benedetto XV, no. 6, 16132, Genoa, Italy.
Carmen PizzorniResearch Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine (Di.M.I.), Polyclinic San Martino Hospital, University of Genova, Viale Benedetto XV, no. 6, 16132, Genoa, Italy.
Massimo GhioResearch Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine (Di.M.I.), Polyclinic San Martino Hospital, University of Genova, Viale Benedetto XV, no. 6, 16132, Genoa, Italy.
Chiara SerioloCentro di Ricerca su Osteoporosi e Patologie Osteoarticolari CROPO, Di.M.I., University of Genova, Genoa, Italy.
Luigi MolfettaCentro di Ricerca su Osteoporosi e Patologie Osteoarticolari CROPO, Di.M.I., University of Genova, Genoa, Italy.
Patrizio OdettiCentro di Ricerca su Osteoporosi e Patologie Osteoarticolari CROPO, Di.M.I., University of Genova, Genoa, Italy.
Vanessa SmithDepartment of Rheumatology, Ghent University Hospital, Ghent, Belgium.
Maurizio CutoloResearch Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine (Di.M.I.), Polyclinic San Martino Hospital, University of Genova, Viale Benedetto XV, no. 6, 16132, Genoa, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this research was to determine any correlations between Dickkopf-1 serum levels (Dkk-1, a natural inhibitor of the Wnt signaling pathway promoting osteoclastogenesis) and the Trabecular Bone Score (TBS), in systemic sclerosis (SSc) and rheumatoid arthritis (RA) patients. It also aimed at determining any difference in Dkk-1 serum levels between SSc and RA patients and a control group (CNT) of healthy subjects. A prospective study was carried out in 60 SSc and 60 RA patients and 60 CNT. Dkk-1 serum levels were evaluated by the ELISA method (Quantikine Human Dkk-1 Immunoassay, R&D System, Minneapolis, USA). The severity of microvascular damage was evaluated by nailfold videocapillaroscopy (NVC patterns: "Early," "Active," "Late"), in the SSc patients. TBS analysis and bone mineral density (BMD, g/cm

Indexed as

AgedArthritis, RheumatoidBone DensityBone RemodelingCancellous BoneCase-Control StudiesFemaleHumansIntercellular Signaling Peptides and ProteinsItalyLinear ModelsMicroscopic AngioscopyMiddle AgedNailsOsteoporosisProspective StudiesDKK1 protein, humanIntercellular Signaling Peptides and ProteinsDickkopf-1OsteoporosisRheumatoid arthritisSystemic sclerosisTrabecular Bone Score

Identifiers

PMID30291470

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.