Evidence map›Paper›PMID 30291431›Full record

ArticlePflugers Archiv : European journal of physiology2019

Carbocisteine stimulated an increase in ciliary bend angle via a decrease in [Cl

Yukiko Ikeuchi, Haruka Kogiso, Shigekuni Hosogi, Saori Tanaka, Chikao Shimamoto, Hitoshi Matsumura, Toshio Inui, Yoshinori Marunaka, Takashi Nakahari

Abstract read
PubMed Publisher
In one paragraph

Article in Pflugers Archiv : European journal of physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Physiological roles of chloride ions in bodily and cellular functions.The journal of physiological sciences : JPS · 2023
    Review
  6. Review
  7. Review
  8. Intracellular ClInternational journal of molecular sciences · 2020
    Review
  9. Airway Ciliary Beating Affected by theInternational journal of molecular sciences · 2020
    Article
  10. Ciliary beating amplitude controlled by intracellular ClPflugers Archiv : European journal of physiology · 2019
    Article
  11. Daidzein-Stimulated Increase in the Ciliary Beating Amplitude via an [ClInternational journal of molecular sciences · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Yukiko IkeuchiDepartment of Molecular Cell Physiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, 602-8566, Japan.
Haruka KogisoDepartment of Molecular Cell Physiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, 602-8566, Japan.
Shigekuni HosogiDepartment of Molecular Cell Physiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, 602-8566, Japan.
Saori TanakaLaboratory of Pharmacotherapy, Osaka University of Pharmaceutical Sciences, Takatsuki, Japan.
Chikao ShimamotoLaboratory of Pharmacotherapy, Osaka University of Pharmaceutical Sciences, Takatsuki, Japan.
Hitoshi MatsumuraLaboratory of Pharmacotherapy, Osaka University of Pharmaceutical Sciences, Takatsuki, Japan.
Toshio InuiResearch Center for Drug Discovery and Pharmaceutical Development Science, Research Organization of Science and Technology, BKC, Ritsumeikan University, 1-1-1 Nojihigashi, Kusatsu, Shiga, 525-8577, Japan.
Yoshinori MarunakaDepartment of Molecular Cell Physiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, 602-8566, Japan.
Takashi NakahariResearch Center for Drug Discovery and Pharmaceutical Development Science, Research Organization of Science and Technology, BKC, Ritsumeikan University, 1-1-1 Nojihigashi, Kusatsu, Shiga, 525-8577, Japan. nakahari@fc.ritsumei.ac.jp.
Kyoto Prefectural University of Medicine · JPOsaka University of Pharmaceutical Sciences · JPRitsumeikan University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Carbocisteine (CCis), a mucoactive agent, is widely used to improve respiratory diseases. This study demonstrated that CCis increases ciliary bend angle (CBA) by 30% and ciliary beat frequency (CBF) by 10% in mouse airway ciliary cells. These increases were induced by an elevation in intracellular pH (pH

Indexed as

AnimalsBicarbonatesCalciumChloridesCiliaCyclic AMP-Dependent Protein KinasesHydrogen-Ion ConcentrationMiceProtein Kinase InhibitorsRespiratory SystemSodiumBicarbonatesCalciumChloridesCyclic AMP-Dependent Protein KinasesProtein Kinase InhibitorsSodiumAirway ciliaCiliary beating angleInner dyneinIntracellular Cl− concentration

Identifiers

PMID30291431
OpenAlexW2895182361

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.