Evidence map›Paper›PMID 30291373›Full record

ReviewEuropean journal of nuclear medicine and molecular imaging2019

FDG PET/CT for assessing tumour response to immunotherapy : Report on the EANM symposium on immune modulation and recent review of the literature.

Nicolas Aide, Rodney J Hicks, Christophe Le Tourneau, Stéphanie Lheureux, Stefano Fanti, Egesta Lopci

Registry-linked trialAbstract readReview
In one paragraph

Review in European journal of nuclear medicine and molecular imaging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03563482 (Correlazione Dell'Imaging Metabolico Con l'Espressione Dei Marcatori Immunitari Nei Pazienti Con NSCLC Candidati All'Immunoterapia.), which is not on this map. Cited by 148 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
148citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03563482 naunknown statusnot on this map

Correlazione Dell'Imaging Metabolico Con l'Espressione Dei Marcatori Immunitari Nei Pazienti Con NSCLC Candidati All'Immunoterapia.

TypeinterventionalSponsorIstituto Clinico HumanitasRan2017 to 2022Enrolled500ConditionsCarcinoma, Non-Small-Cell Lung, Positron-Emission Tomography, ImmunotherapyArmsPET scan
3 · Its place in the literature

Who cites it

148 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. The value ofEuropean journal of nuclear medicine and molecular imaging · 2021
    Pooled it
  2. Predictive Performance of Serum S100BFrontiers in oncology · 2021
    Pooled it
  3. Trial
  4. Predictive value of [European journal of nuclear medicine and molecular imaging · 2025
    Trial
  5. Trial
  6. Trial
  7. Trial
  8. [European journal of nuclear medicine and molecular imaging · 2022
    Trial
  9. Trial
  10. Trial
  11. Trial
  12. Trial
  13. Review
  14. Review
  15. Compatibility of different PET/CT criteria in evaluating treatment response and survival in non-small cell lung cancer patients treated with immunotherapy.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Article
  16. Review
  17. Review
  18. Article
  19. Baseline immune-organFrontiers in medicine · 2026
    Article
  20. Imaging Immunotherapy.Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2026
    Review

88 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Nicolas AideNuclear Medicine Department, Caen University Hospital, Caen, France. aide-n@chu-caen.fr.ORCID http://orcid.org/0000-0001-9207-0847
Rodney J HicksCentre for Molecular Imaging, Department of Cancer Imaging, Peter MacCallum Cancer, Melbourne, Australia.
Christophe Le TourneauDepartment of Medical Oncology, Institut Curie, Paris & Saint-Cloud, France.
Stéphanie LheureuxPrincess Margaret Cancer Centre, Department of Medical Oncology, University of Toronto, Toronto, ON, Canada.
Stefano FantiEANM Oncology Committee, Vienna, Austria.
Egesta LopciEANM Oncology Committee, Vienna, Austria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This paper follows the immunotherapy symposium held during the European Association of Nuclear Medicine (EANM) 2017 Annual Congress. The biological basis of the immune checkpoint inhibitors and the drugs most frequently used for the treatment of solid tumours are reviewed. The issues of pseudoprogression (frequency, timeline), hyperprogression and immune-related side effects are discussed, as well as their implications for patient management. A review of the recent literature on the use of FDG PET for assessment of immunotherapy is presented, and recommendations are provided for assessing tumour response and reporting immune-related side effects with FDG PET based on published data and experts' experience. Representative clinical cases are also discussed.

Indexed as

Congresses as TopicImmunotherapyFluorodeoxyglucose F18HumansNeoplasmsPositron Emission Tomography Computed TomographyPractice Guidelines as TopicRadiopharmaceuticalsTreatment OutcomeFluorodeoxyglucose F18RadiopharmaceuticalsHyperprogressionImmune checkpoint inhibitorsImmune-related side effectsImmunotherapyPseudoprogressionTherapy response

Identifiers

PMID30291373
PMCPMC6267687

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.