Evidence map›Paper›PMID 30291337›Full record

ArticleLeukemia2019

Bone marrow hematopoietic dysfunction in untreated chronic lymphocytic leukemia patients.

Bryce A Manso, Henan Zhang, Molly G Mikkelson, Kimberly A Gwin, Charla R Secreto, Wei Ding, Sameer A Parikh, Neil E Kay, Kay L Medina

Abstract read
In one paragraph

Article in Leukemia, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 27 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Bryce A MansoMayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic, Rochester, MN, 55905, USA.ORCID http://orcid.org/0000-0002-4860-4888
Henan ZhangDivision of Hematology, Mayo Clinic, Rochester, MN, 55905, USA.
Molly G MikkelsonDepartment of Immunology, Mayo Clinic, Rochester, MN, 55905, USA.
Kimberly A GwinDepartment of Immunology, Mayo Clinic, Rochester, MN, 55905, USA.
Charla R SecretoDivision of Hematology, Mayo Clinic, Rochester, MN, 55905, USA.
Wei DingDivision of Hematology, Mayo Clinic, Rochester, MN, 55905, USA.
Sameer A ParikhDivision of Hematology, Mayo Clinic, Rochester, MN, 55905, USA.
Neil E KayDivision of Hematology, Mayo Clinic, Rochester, MN, 55905, USA.
Kay L MedinaDepartment of Immunology, Mayo Clinic, Rochester, MN, 55905, USA. Medina.Kay@mayo.edu.
Mayo Clinic · USMayo Clinic in Arizona · US

Funding

PHD TRAINING PROGRAM IN BASIC IMMUNOLOGYT32AI007425 · NIAID · MAYO CLINIC ROCHESTER · PI SHAPIRO, VIRGINIA SMITH · 1995 to 2020
$3.6M
NIAID NIH HHS T32 AI007425
6 · The paper itself

Abstract

The consequences of immune dysfunction in B-chronic lymphocytic leukemia (CLL) likely relate to the incidence of serious recurrent infections and second malignancies that plague CLL patients. The well-described immune abnormalities are not able to consistently explain these complications. Here, we report bone marrow (BM) hematopoietic dysfunction in early and late stage untreated CLL patients. Numbers of CD34

Indexed as

AdultAgedAged, 80 and overAntigens, CD34Bone MarrowBone Marrow CellsFemaleFlow CytometryGATA1 Transcription FactorGATA2 Transcription FactorHematopoietic Stem CellsHumansHypoxia-Inducible Factor 1, alpha SubunitKiller Cells, NaturalLeukemia, Lymphocytic, Chronic, B-CellMaleAntigens, CD34GATA1 Transcription FactorGATA2 Transcription FactorHypoxia-Inducible Factor 1, alpha SubunitProto-Oncogene ProteinsProto-Oncogene Protein Spi-1Trans-ActivatorsTumor Necrosis Factor-alpha

Identifiers

PMID30291337
PMCPMC6497058
OpenAlexW2895286071

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.