ArticleScientific reports2018
Phylogenetics of Mycoplasma hominis clinical strains associated with gynecological infections or infertility as disclosed by an expanded multilocus sequence typing scheme.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Mycoplasma agassizii Multilocus Sequence Typing Using Nanopore Sequencing: Insights Into Genetic Diversity and Isolate Characterization.Annals of the New York Academy of Sciences · 2025Article
- New Trends in Sexually Transmitted Infections Among Adolescents and Young People: Epidemiology, Clinical and Diagnostic Management.Microorganisms · 2025Review
- A genome-wide investigation ofFrontiers in microbiology · 2025Article
- Article
- An overview regarding the relationship between Mollicutes, infertility and antibiotic resistance (Review).Biomedical reports · 2024Review
- MinisculeSustainable microbiology · 2024Review
- Clinical and Microbiological Characterization of Bloodstream Infections Caused by Mycoplasma hominis: An Overlooked Pathogen.Infectious diseases and therapy · 2022Article
- Defining Fluoroquinolone Resistance-Mediating Mutations from Non-Resistance Polymorphisms inAntibiotics (Basel, Switzerland) · 2021Article
- Sequence analysis reveals asymptomatic infection withInternational journal of reproductive biomedicine · 2021Article
- Multilocus sequence typing of pathogenic Mycoplasma mycoides subsp. capri reveals the predominance of a novel clonal complex among isolates from goats in India.Archives of microbiology · 2021Article
- Tetracycline Resistance Mediated byAntimicrobial agents and chemotherapy · 2021Article
- The Relationship betweenJournal of oncology · 2021Review
- Mycoplasmas-Host Interaction: Mechanisms of Inflammation and Association with Cellular Transformation.Microorganisms · 2020Review
- Clonal Spread of Tetracycline Resistance AmongInfection and drug resistance · 2020Article
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5 authors.
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Abstract
To our knowledge, the phylodistribution of M. hominis clinical strains associated with various pathological conditions of the urogenital tract has not been explored hitherto. Here we analyzed the genetic diversity and phylogenetic relationships among 59 M. hominis Tunisian clinical isolates, categorized as gynecological infections- or infertility-associated pathotypes. For this purpose, we developed an expanded multilocus sequence typing (eMLST) scheme, combining the previously reported multilocus sequence typing (MLST) loci (gyrB, tuf, ftsY, uvrA, gap) with a new selected set of putative virulence genes (p120', vaa, lmp1, lmp3, p60), referred herein to as multi-virulence-locus sequence typing (MVLST) loci. In doing so, M. hominis population was segregated into two distinct genetic lineages, which were differentially associated with each pathotype. Such a clear dichotomy was supported by several phylogenetic and population genetic analysis tools. Recombination was found to take place, but not sufficient enough to break down the overall clonal population structure of M. hominis, most likely as a result of purifying selection, which accommodated the most fit clones. In sum, and owing to the eMLST scheme described herein, we provide insightful data on the phylogenetics of M. hominis, arguing for the existence of genetically differentiable urogenital pathotypes.
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