ArticleScientific reports2018
VOC breath profile in spontaneously breathing awake swine during Influenza A infection.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 78 citations in OpenAlex.
- A comprehensive meta-analysis and systematic review of breath analysis in detection of COVID-19 through Volatile organic compounds.Diagnostic microbiology and infectious disease · 2024Pooled it
- The potential of volatile organic compounds-based breath analysis for COVID-19 screening: a systematic review & meta-analysis.Diagnostic microbiology and infectious disease · 2022Pooled it
- Exploratory analysis of exhaled volatile organic compounds for binary discrimination between lung cancer, pneumonia, and healthy controls using machine learning.Frontiers in medicine · 2026Article
- An engineered culture vessel and flow system to improve the in vitro analysis of volatile organic compounds.Communications engineering · 2025Article
- Article
- High and low pathogenicity avian influenza virus discrimination and prediction based on volatile organic compounds signature by SIFT-MS: a proof-of-concept study.Scientific reports · 2024Article
- Effects of Contagious Respiratory Pathogens on Breath Biomarkers.Antioxidants (Basel, Switzerland) · 2024Article
- Volatilomes of human infection.Analytical and bioanalytical chemistry · 2024Review
- Origin of breath isoprene in humans is revealed via multi-omic investigations.Communications biology · 2023Article
- Alloferon and Zanamivir Show Effective Antiviral Activity against Influenza A Virus (H1N1) Infection In Vitro and In Vivo.International journal of molecular sciences · 2022Article
- Advanced setup for safe breath sampling and patient monitoring under highly infectious conditions in the clinical environment.Scientific reports · 2022Article
- Profiling of exhaled volatile organics in the screening scenario of a COVID-19 test center.iScience · 2022Article
- Sustainable solutions for indoor pollution abatement during COVID phase: A critical study on current technologies & challenges.Journal of hazardous materials advances · 2022Article
- Air Ambulance: Antimicrobial Power of Bacterial Volatiles.Antibiotics (Basel, Switzerland) · 2022Review
- Expert considerations and consensus for using dogs to detect human SARS-CoV-2-infections.Frontiers in medicine · 2022Article
- Breath Metabolites to Diagnose Infection.Clinical chemistry · 2021Review
- Metabolomics Diagnosis of COVID-19 from Exhaled Breath Condensate.Metabolites · 2021Article
- Influenza A H1N1 Induced Disturbance of the Respiratory and Fecal Microbiome of German Landrace Pigs - a Multi-Omics Characterization.Microbiology spectrum · 2021Article
- Exhaled breath biomarkers of influenza infection and influenza vaccination.Journal of breath research · 2021Article
- Breath-Based Diagnosis of Infectious Diseases: A Review of the Current Landscape.Clinics in laboratory medicine · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Influenza is one of the most common causes of virus diseases worldwide. Virus detection requires determination of Influenza RNA in the upper respiratory tract. Efficient screening is not possible in this way. Analysis of volatile organic compounds (VOCs) in breath holds promise for non-invasive and fast monitoring of disease progression. Breath VOC profiles of 14 (3 controls and 11 infected animals) swine were repeatedly analyzed during a complete infection cycle of Influenza A under high safety conditions. Breath VOCs were pre-concentrated by means of needle trap micro-extraction and analysed by gas chromatography mass spectrometry before infection, during virus presence in the nasal cavity, and after recovery. Six VOCs could be related to disease progression: acetaldehyde, propanal, n-propyl acetate, methyl methacrylate, styrene and 1,1-dipropoxypropane. As early as on day four after inoculation, when animals were tested positive for Influenza A, differentiation between control and infected animals was possible. VOC based information on virus infection could enable early detection of Influenza A. As VOC analysis is completely non-invasive it has potential for large scale screening purposes. In a perspective, breath analysis may offer a novel tool for Influenza monitoring in human medicine, animal health control or border protection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.