ArticleNature communications2018
Dynamic intercellular transport modulates the spatial patterning of differentiation during early neural commitment.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Top-down perspectives on cell membrane potential and protein transcription.Scientific reports · 2025Article
- Topological data analysis of pattern formation of human induced pluripotent stem cell colonies.Scientific reports · 2025Article
- EZH2 inhibition sensitizes retinoic acid-driven senescence in synovial sarcoma.Cell death & disease · 2024Article
- Multicellular adaptation to electrophysiological perturbations analyzed by deterministic and stochastic bioelectrical models.Scientific reports · 2024Article
- Article
- Engineering multicellular living systems-a Keystone Symposia report.Annals of the New York Academy of Sciences · 2022Article
- Connexins Signatures of the Neurovascular Unit and Their Physio-Pathological Functions.International journal of molecular sciences · 2022Review
- Protease-controlled secretion and display of intercellular signals.Nature communications · 2022Article
- Cell Systems Bioelectricity: How Different Intercellular Gap Junctions Could Regionalize a Multicellular Aggregate.Cancers · 2021Article
- A bioelectric model of carcinogenesis, including propagation of cell membrane depolarization and reversal therapies.Scientific reports · 2021Article
- Deep neural net tracking of human pluripotent stem cells reveals intrinsic behaviors directing morphogenesis.Stem cell reports · 2021Article
- Visualization and quantification of dynamic intercellular coupling in human embryonic stem cells using single cell sonoporation.Scientific reports · 2020Article
- A Co-registration Pipeline for Multimodal MALDI and Confocal Imaging Analysis of Stem Cell Colonies.Journal of the American Society for Mass Spectrometry · 2020Article
- Using Acoustic Fields to Fabricate ECM-Based Biomaterials for Regenerative Medicine Applications.Recent progress in materials · 2020Article
- Modeling somatic computation with non-neural bioelectric networks.Scientific reports · 2019Article
- Automated Design of Pluripotent Stem Cell Self-Organization.Cell systems · 2019Article
- Multi-cellular engineered living systems: building a community around responsible research on emergence.Biofabrication · 2019Article
- Agent-based modeling of morphogenetic systems: Advantages and challenges.PLoS computational biology · 2019Review
- Article
Corrections and comments
- Erratum issued
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The initiation of heterogeneity within a population of phenotypically identical progenitors is a critical event for the onset of morphogenesis and differentiation patterning. Gap junction communication within multicellular systems produces complex networks of intercellular connectivity that result in heterogeneous distributions of intracellular signaling molecules. In this study, we investigate emergent systems-level behavior of the intercellular network within embryonic stem cell (ESC) populations and corresponding spatial organization during early neural differentiation. An agent-based model incorporates experimentally-determined parameters to yield complex transport networks for delivery of pro-differentiation cues between neighboring cells, reproducing the morphogenic trajectories during retinoic acid-accelerated mouse ESC differentiation. Furthermore, the model correctly predicts the delayed differentiation and preserved spatial features of the morphogenic trajectory that occurs in response to intercellular perturbation. These findings suggest an integral role of gap junction communication in the temporal coordination of emergent patterning during early differentiation and neural commitment of pluripotent stem cells.
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