ArticleNature communications2018
Orthogonal programming of heterogeneous micro-mechano-environments and geometries in three-dimensional bio-stereolithography.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 86 citations in OpenAlex.
- UV-Induced Self-Renewing Wear-Resistant Flexible Polymer from a Polyurethane/Thiol-Ene Hybrid System.Materials (Basel, Switzerland) · 2026Article
- Hydrogel Microspheres for Biomedical Applications.Small science · 2026Review
- 3D printing-biomimetic local stiff niche enhances glycolysis to boost PDAC cell stem-like phenotype via N6-methyladenosine-suppressed YAP1 mRNA decay.Materials today. Bio · 2025Article
- Article
- Microfluidic harvesting of breast cancer tumor spheroid-derived extracellular vesicles from immobilized microgels for single-vesicle analysis.Lab on a chip · 2022Article
- Bioprinted microvasculature: progressing from structure to function.Biofabrication · 2022Review
- Sorting Gold and Sand (Silica) Using Atomic Force Microscope-Based Dielectrophoresis.Nano-micro letters · 2021Article
- Rapid Scan EPR Oxygen Imaging in Photoactivated Resin Used for Stereolithographic 3D Printing.3D printing and additive manufacturing · 2021Article
- Accelerated discovery of 3D printing materials using data-driven multiobjective optimization.Science advances · 2021Article
- Quantitative developmental biology in vitro using micropatterning.Development (Cambridge, England) · 2021Review
- Tethered and Untethered 3D Microactuators Fabricated by Two-Photon Polymerization: A Review.Micromachines · 2021Review
- Microscale Photopatterning of Through-thickness Modulus in a Monolithic and Functionally Graded 3D Printed Part.Small science · 2021Article
- Photosynthesis-assisted remodeling of three-dimensional printed structures.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- 3D printing of inherently nanoporous polymers via polymerization-induced phase separation.Nature communications · 2021Article
- Direct printing of functional 3D objects using polymerization-induced phase separation.Nature communications · 2021Article
- Printability and Shape Fidelity of Bioinks in 3D Bioprinting.Chemical reviews · 2020Review
- Layer-by-Layer Printing of Photopolymers in 3D: How Weak is the Interface?ACS applied materials & interfaces · 2020Article
- 3D printing using powder melt extrusion.Additive manufacturing · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Engineering heterogeneous micro-mechano-microenvironments of extracellular matrix is of great interest in tissue engineering, but spatial control over mechanical heterogeneity in three dimensions is still challenging given the fact that geometry and stiffness are inherently intertwined in fabrication. Here, we develop a layer-by-layer three-dimensional (3D) printing paradigm which achieves orthogonal control of stiffness and geometry by capitalizing on the conventionally adverse effect of oxygen inhibition on free-radical polymerization. Controlled oxygen permeation and inhibition result in photo-cured hydrogel layers with thicknesses only weakly dependent to the ultraviolet exposure dosage. The dosage is instead leveraged to program the crosslink density and stiffness of the cured structures. The programmable stiffness spans nearly an order of magnitude (E ~ 2-15 kPa) within the physiologically relevant range. We further demonstrate that extracellular matrices with programmed micro-mechano-environments can dictate 3D cellular organization, enabling in vitro tissue reconstruction.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.