ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2018
Instantaneous Midbrain Control of Saccade Velocity.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 62 citations in OpenAlex.
- Eye-head coordination during goal-directed orienting in mice.Communications biology · 2026Article
- Eye-head coordination during goal-directed orienting in mice.bioRxiv : the preprint server for biology · 2026Article
- Multiple groups of neurons in the superior colliculus convert value signals into saccadic vigor.iScience · 2026Article
- Article
- Modeling kinematic variability reveals displacement and velocity based dual control of saccadic eye movements.Experimental brain research · 2024Article
- Gazing into spatiotemporal 'known unknowns': the influence of uncertainty on pupil size and saccadic eye movements.Scientific reports · 2024Article
- Sensory tuning in neuronal movement commands.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Neural encoding of instantaneous kinematics of eye-head gaze shifts in monkey superior Colliculus.Communications biology · 2023Article
- Rapid Input-Output Transformation between Local Field Potential and Spiking Activity during Sensation but not Action in the Superior Colliculus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Ventral premotor cortex encodes task relevant features during eye and head movements.Scientific reports · 2022Article
- Saccade vigor reflects the rise of decision variables during deliberation.Current biology : CB · 2022Article
- Superior colliculus saccade motor bursts do not dictate movement kinematics.Communications biology · 2022Article
- Population temporal structure supplements the rate code during sensorimotor transformations.Current biology : CB · 2022Article
- Eye Movement Abnormalities in Glaucoma Patients: A Review.Eye and brain · 2022Review
- Frontal eye field inactivation alters the readout of superior colliculus activity for saccade generation in a task-dependent manner.Journal of computational neuroscience · 2021Article
- Article
- Eye movement performance and clinical outcomes among female athletes post-concussion.Brain injury · 2020Article
- Article
- Slow-fast control of eye movements: an instance of Zeeman's model for an action.Biological cybernetics · 2020Article
- Successful visually guided eye movements following sight restoration after congenital cataracts.Journal of vision · 2020Article
Corrections and comments
- Commented on by
Authors and funding
3 authors at 1 institution in 2 countries.
Funding
Abstract
The ability to interact with our environment requires the brain to transform spatially represented sensory signals into temporally encoded motor commands for appropriate control of the relevant effectors. For visually guided eye movements, or saccades, the superior colliculus (SC) is assumed to be the final stage of spatial representation, and instantaneous control of the movement is achieved through a rate code representation in the lower brain stem. We investigated whether SC activity in nonhuman primates (Macaca mulatta, 2 male and 1 female) also uses a dynamic rate code, in addition to the spatial representation. Noting that the kinematics of amplitude-matched movements exhibit trial-to-trial variability, we regressed instantaneous SC activity with instantaneous eye velocity and found a robust correlation throughout saccade duration. Peak correlation was tightly linked to time of peak velocity, the optimal efferent delay between SC activity and eye velocity was constant at ∼12 ms both at onset and during the saccade, and SC neurons with higher firing rates exhibited stronger correlations. Moreover, the strong correlative relationship and constant efferent delay observation were preserved when eye movement profiles were substantially altered by a blink-induced perturbation. These results indicate that the rate code of individual SC neurons can control instantaneous eye velocity and argue against a serial process of spatial-to-temporal transformation. They also motivated us to consider a new framework of saccade control that does not incorporate traditionally accepted elements, such as the comparator and resettable integrator, whose neural correlates have remained elusive.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.