Evidence map›Paper›PMID 30291203›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2018

Haiyue Zhang, Yuguo Xia, Qing Ye, Fang Yu, Wen Zhu, Peiying Li, Zhishuo Wei, Yuanyuan Yang, Yejie Shi, Angus W Thomson and 2 more

Abstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

75 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Ghrelin Recruits the Endocannabinoid System to Modulate Food Reward.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  13. Treg Upregulation by Treadmill Training Accelerates Myelin Repair Post-Ischemia.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2025
    Article
  14. Review
  15. CD19Frontiers in immunology · 2025
    Article
  16. CD4Frontiers in immunology · 2025
    Review
  17. Review
  18. Article
  19. Review
  20. Review

15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Haiyue ZhangPittsburgh Institute of Brain Disorders and Recovery, and Department of Neurology.
Yuguo XiaPittsburgh Institute of Brain Disorders and Recovery, and Department of Neurology.
Qing YePittsburgh Institute of Brain Disorders and Recovery, and Department of Neurology.
Fang YuPittsburgh Institute of Brain Disorders and Recovery, and Department of Neurology.
Wen ZhuPittsburgh Institute of Brain Disorders and Recovery, and Department of Neurology.
Peiying LiPittsburgh Institute of Brain Disorders and Recovery, and Department of Neurology.ORCID 0000-0002-5721-9914
Zhishuo WeiPittsburgh Institute of Brain Disorders and Recovery, and Department of Neurology.
Yuanyuan YangPittsburgh Institute of Brain Disorders and Recovery, and Department of Neurology.
Yejie ShiPittsburgh Institute of Brain Disorders and Recovery, and Department of Neurology.
Angus W ThomsonStarzl Transplantation Institute, Department of Surgery and Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, and.
Jun ChenPittsburgh Institute of Brain Disorders and Recovery, and Department of Neurology, hux2@upmc.edu chenj2@upmc.edu.ORCID 0000-0002-8077-3403
Xiaoming HuPittsburgh Institute of Brain Disorders and Recovery, and Department of Neurology, hux2@upmc.edu chenj2@upmc.edu.ORCID 0000-0002-5857-6243

Funding

Immunomodulation of white matter integrity after strokeR01NS092618 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HU, XIAOMING · 2015 to 2020
$1.7M
Regulatory T cell as a restorative therapy for ischemic strokeR01NS094573 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SUN, DANDAN · 2016 to 2021
$1.7M
Inflammation resolution, neuroprotection, and brain repair to promote stroke recoveryR01NS105430 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHEN, JUN · 2017 to 2021
$1.6M
NINDS NIH HHS R01 NS092618NINDS NIH HHS R01 NS094573NINDS NIH HHS R01 NS105430
6 · The paper itself

Abstract

Regulatory T cells (Tregs) are known to protect against ischemic stroke. However, the low frequency of Tregs restricts their clinical utility. This study investigated whether expanding the number of Tregs

Indexed as

AnimalsAntibodies, MonoclonalImmunotherapyInterleukin-2Ischemic Attack, TransientMaleMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicStrokeT-Lymphocytes, RegulatoryAntibodies, MonoclonalInterleukin-2cerebral ischemiaIL-2/IL-2 antibody complexneuroprotectionregulatory T cells

Identifiers

PMID30291203
PMCPMC6246882

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.