Evidence map›Paper›PMID 30291194›Full record

Trial reportJournal of nuclear medicine : official publication, Society of Nuclear Medicine2019

Efficacy and Safety of High-Specific-Activity

Daniel A Pryma, Bennett B Chin, Richard B Noto, Joseph S Dillon, Stephanie Perkins, Lilja Solnes, Lale Kostakoglu, Aldo N Serafini, Miguel H Pampaloni, Jessica Jensen and 9 more

Open access · hybridAbstract readClinical TrialMulticenter Study
In one paragraph

Trial report in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 149 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
149citing papers in PubMed, 3 pooled it
22.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

149 citing papers in PubMed, 3 syntheses or guidelines pooled it, 274 citations in OpenAlex.

  1. Pooled it
  2. Response to targeted radionuclide therapy with [Frontiers in endocrinology · 2022
    Pooled it
  3. Multidisciplinary practice guidelines for the diagnosis, genetic counseling and treatment of pheochromocytomas and paragangliomas.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2021
    Guideline
  4. Trial
  5. Article
  6. Review
  7. First-in-Human, Open-label, Single-Arm Phase I Study of [211At] meta-Astatobenzylguanidine in Patients with Pheochromocytoma or Paraganglioma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2026
    Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. Pheochromocytomas and Paragangliomas.Endocrinology and metabolism clinics of North America · 2026
    Review
  14. Article
  15. A Phase 0 Imaging Trial of [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Article
  16. Article
  17. Article
  18. [European journal of nuclear medicine and molecular imaging · 2026
    Article
  19. Article
  20. Clinical Applications of Theranostics.Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2026
    Review

89 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 11 institutions in 1 country.

Daniel A PrymaDepartment of Radiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania daniel.pryma@uphs.upenn.edu.
Bennett B ChinDepartment of Radiology-Nuclear Medicine, University of Colorado Anschutz Medical Campus, Denver, Colorado.
Richard B NotoDivision of Nuclear Medicine, Rhode Island Hospital/Warren Alpert Medical School of Brown University, Providence, Rhode Island.
Joseph S DillonDepartment of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa.
Stephanie PerkinsDepartment of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri.
Lilja SolnesDepartment of Radiology and Radiological Science, Johns Hopkins Medicine, Baltimore, Maryland.
Lale KostakogluDepartment of Nuclear Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.
Aldo N SerafiniDivision of Nuclear Medicine, University of Miami School of Medicine, Miami, Florida.
Miguel H PampaloniDepartment of Radiology and Biomedical Imaging, University of California at San Francisco School of Medicine, San Francisco, California.
Jessica JensenDepartment of Research and Development, Progenics Pharmaceuticals, Inc., New York, New York; and.
Thomas ArmorDepartment of Research and Development, Progenics Pharmaceuticals, Inc., New York, New York; and.
Tess LinDepartment of Research and Development, Progenics Pharmaceuticals, Inc., New York, New York; and.
Theresa WhiteDepartment of Research and Development, Progenics Pharmaceuticals, Inc., New York, New York; and.
Nancy StamblerDepartment of Research and Development, Progenics Pharmaceuticals, Inc., New York, New York; and.
Stuart ApfelDepartment of Research and Development, Progenics Pharmaceuticals, Inc., New York, New York; and.
Vincent A DiPippoDepartment of Research and Development, Progenics Pharmaceuticals, Inc., New York, New York; and.
Syed MahmoodDepartment of Research and Development, Progenics Pharmaceuticals, Inc., New York, New York; and.
Vivien WongDepartment of Research and Development, Progenics Pharmaceuticals, Inc., New York, New York; and.
Camilo JimenezDepartment of Endocrine Neoplasia and Hormonal Disorders, University of Texas M.D. Anderson Cancer Center, Houston, Texas.
Progenics Pharmaceuticals (United States) · USBrown University · USIcahn School of Medicine at Mount Sinai · USJohns Hopkins Medicine · USThe University of Texas MD Anderson Cancer Center · USUniversity of California, San Francisco · USUniversity of Colorado Anschutz Medical Campus · USUniversity of Iowa · USUniversity of Miami · USUniversity of Pennsylvania · USWashington University in St. Louis · US

Funding

Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Christopher K Laubenthal · 2000 to 2026
$70.0M
Project 4: New Approaches to Improving the Effectiveness of Radionuclide Targeted Treatments in Neuroendocrine TumorsP50CA174521 · NCI · UNIVERSITY OF IOWA · PI ODORISIO, THOMAS · 2015 to 2021
$13.2M
NCI NIH HHS P50 CA174521
6 · The paper itself

Abstract

Patients with metastatic or unresectable (advanced) pheochromocytoma and paraganglioma (PPGL) have poor prognoses and few treatment options. This multicenter, phase 2 trial evaluated the efficacy and safety of high-specific-activity

Indexed as

Safety3-IodobenzylguanidineAdolescentAdrenal Gland NeoplasmsBiomarkers, TumorFemaleHumansMaleParagangliomaPheochromocytomaSurvival AnalysisTreatment Outcome3-IodobenzylguanidineBiomarkers, Tumorhigh-specific-activity 131I-MIBGneuroendocrine tumorsparagangliomapheochromocytomarareultra-orphan disease

Identifiers

PMID30291194
PMCPMC6495236
OpenAlexW2895476867

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.