Evidence map›Paper›PMID 30291168›Full record

Observational studyPediatrics2018

Antecedents of Obesity Among Children Born Extremely Preterm.

Charles T Wood, Olivia Linthavong, Eliana M Perrin, Alan Leviton, Elizabeth N Allred, Karl C K Kuban, T Michael O'Shea, ELGAN Study Investigators

Open access · bronzeAbstract readMulticenter StudyObservational Study
In one paragraph

Observational study in Pediatrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 2 pooled it
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Association of Gestational Age in a Full Range With Childhood Overweight and Obesity: A Systematic Scoping Review.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025
    Article
  6. Article
  7. Observational
  8. Article
  9. Article
  10. Expected and Desirable Preterm and Small Infant Growth Patterns.Advances in nutrition (Bethesda, Md.) · 2024
    Review
  11. Article
  12. Review
  13. Article
  14. Extreme prematurity: Risk and resiliency.Current problems in pediatric and adolescent health care · 2022
    Review
  15. Article
  16. Article
  17. Article
  18. Critical examination of relationships between early growth and childhood overweight in extremely preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2021
    Article
  19. Pre-pregnancy body mass index, gestational weight gain and postnatal growth in preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2021
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Charles T WoodDivision of Primary Care Pediatrics, Department of Pediatrics, Duke Center for Childhood Obesity Research, School of Medicine, Duke University, Durham, North Carolina; charles.wood@duke.edu.
Olivia LinthavongDivision of Neonatal-Perinatal Medicine, Department of Pediatrics, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Eliana M PerrinDivision of Primary Care Pediatrics, Department of Pediatrics, Duke Center for Childhood Obesity Research, School of Medicine, Duke University, Durham, North Carolina.
Alan LevitonDepartment of Neurology, Harvard Medical School, Harvard University and Neuroepidemiology Unit, and Department of Neurology, Boston Children's Hospital, Boston, Massachusetts; and.
Elizabeth N AllredDepartment of Neurology, Harvard Medical School, Harvard University and Neuroepidemiology Unit, and Department of Neurology, Boston Children's Hospital, Boston, Massachusetts; and.
Karl C K KubanDepartment of Pediatrics, Boston Medical Center, Boston University, Boston, Massachusetts.
T Michael O'SheaDivision of Neonatal-Perinatal Medicine, Department of Pediatrics, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
ELGAN Study Investigators
Duke University · USUniversity of North Carolina at Chapel Hill · USBoston Children's Hospital · USBoston University · USHarvard University · US

Funding

Neonatal Biomarkers in Extremely Preterm Babies Predict Childhood Brain DisordersU01NS040069 · NINDS · CHILDREN'S HOSPITAL BOSTON · PI KUBAN, KARL · 2001 to 2014
$34.0M
The Role of the Placenta-Brain Axis in Children's NeurodevelopmentUH3OD023348 · OD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Rebecca Fry, Michael O'SHEA · 2018 to 2026
$21.9M
Environment, Epigenetics, Neurodevelopment & Health of Extremely Preterm ChildrenUG3OD023348 · OD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FRY, REBECCA, O'SHEA, MICHAEL · 2016 to 2024
$7.4M
NIH HHS UG3 OD023348NIH HHS UH3 OD023348NINDS NIH HHS U01 NS040069
6 · The paper itself

Abstract

backgroundChildhood obesity is a pervasive public health problem with risk factors such as maternal prepregnancy BMI and rapid infant weight gain. Although catch-up weight gain promotes more favorable neurodevelopment among infants born preterm, it is not clear whether faster weight gain early in life, or other correlates of preterm birth, are associated with later obesity in this population.

methodsWe used prospective data from the multicenter, observational Extremely Low Gestational Age Newborn Study. Among 1506 eligible individuals in the initial cohort, 1198 were eligible for follow-up at 10 years of age. We examined BMI in 871 children (58% of the cohort; 74% of survivors) and analyzed relationships between antecedents and overweight or obesity at 10 years of age. A time-oriented approach to multinomial multivariable regression enabled us to calculate odds of overweight and obesity associated with pre- and postnatal antecedents.

resultsPrepregnancy maternal BMI ≥25 and top quartile infant weight gain in the first year were associated with increased risk of both overweight and obesity at 10 years of age. Single marital status was a risk factor for later child obesity and exposure to tobacco smoke was a risk factor for later child overweight.

conclusionsThe risk profiles for overweight and obesity at 10 years of age among children born extremely preterm appear to be similar to the risk profiles of overweight and obesity among children born at term.

Indexed as

Body Mass IndexChildChild, PreschoolFemaleFollow-Up StudiesHumansInfantInfant, Extremely PrematureInfant, NewbornPediatric ObesityPregnancyPrenatal Exposure Delayed EffectsProspective StudiesRisk FactorsWeight Gain

Identifiers

PMID30291168
PMCPMC6317645
OpenAlexW2895104972

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.