Evidence map›Paper›PMID 30291167›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2018

Helminth-Induced Production of TGF-β and Suppression of Graft-versus-Host Disease Is Dependent on IL-4 Production by Host Cells.

Yue Li, Xiaoqun Guan, Weiren Liu, Hung-Lin Chen, Jamie Truscott, Sonay Beyatli, Ahmed Metwali, George J Weiner, Nicholas Zavazava, Richard S Blumberg and 4 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Trickle infection withFrontiers in immunology · 2022
    Article
  9. Article
  10. Article
  11. The Anti-Inflammatory Immune Response in EarlyJournal of immunology (Baltimore, Md. : 1950) · 2021
    Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Yue LiDepartment of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242.ORCID 0000-0001-7190-5454
Xiaoqun GuanDepartment of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242.
Weiren LiuDepartment of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242.ORCID 0000-0002-1884-491X
Hung-Lin ChenDepartment of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242.
Jamie TruscottDepartment of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, IA 52242.
Sonay BeyatliDepartment of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242.
Ahmed MetwaliDepartment of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242.
George J WeinerDepartment of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242.ORCID 0000-0003-3427-0562
Nicholas ZavazavaDepartment of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242.
Richard S BlumbergDepartment of Internal Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115.
Joseph F UrbanDiet, Genomics, and Immunology Laboratory, Beltsville Human Nutrition Research Center, Agricultural Research Service, U.S. Department of Agriculture, Beltsville, MD 20705; and.ORCID 0000-0002-1590-8869
Bruce R BlazarDivision of Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota, Minneapolis, MN 55455.ORCID 0000-0002-9608-9841
David E ElliottDepartment of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242.
M Nedim InceDepartment of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242; m-nedim-ince@uiowa.edu.
University of Iowa · USAgricultural Research Service · USBrigham and Women's Hospital · USUniversity of Minnesota · US

Funding

Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Christopher K Laubenthal · 2000 to 2026
$70.0M
Transplant Tolerance in Non-Human PrimatesU19AI051731 · NIAID · UNIVERSITY OF WESTERN ONTARIO · PI ADAMS, ANDREW B · 2002 to 2022
$54.1M
Pulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI Jong Sung Kim · 1990 to 2026
$40.5M
Novel Biologic Therapies for GVHDR01HL095791 · NHLBI · SEATTLE CHILDREN'S HOSPITAL · PI KEAN, LESLIE S · 2010 to 2025
$13.3M
MOLECULAR CHARACTERIZATION OF MUCOSAL LYMPHOCYTESR01DK044319 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI Richard S Blumberg · 1992 to 2026
$10.4M
Enhancing Treg Therapeutic Efficacy in GVHDR01HL118979 · NHLBI · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R, HIPPEN, KELI L · 2014 to 2025
$6.7M
IN VIVO PREVENTION OF MURINE GVHDR01AI034495 · NIAID · UNIVERSITY OF MINNESOTA TWIN CITIES · PI BLAZAR, BRUCE R · 1993 to 2016
$6.2M
T-CELL TARGETING FOR GVHDR01HL056067 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI BLAZAR, BRUCE R · 1995 to 2022
$5.4M
In Vivo Prevention of Murine GVHDR37AI034495 · NIAID · UNIVERSITY OF MINNESOTA · PI Bruce R Blazar · 2017 to 2026
$5.4M
T CELL TARGETING FOR GVHDR37HL056067 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI BLAZAR, BRUCE R. · 1998 to 2007
$3.2M
Management of GVHD and GVT by in vivo generated regulatory T cellsR56AI116715 · NIAID · UNIVERSITY OF IOWA · PI INCE, MIRAC NEDIM · 2015 to 2015
$378k
Modulation of Th17 plasticity by intestinal paleobiomic faunaI01BX002715 · VA · IOWA CITY VA MEDICAL CENTER · PI ELLIOTT, DAVID E · 2015 to 2023
–
BLRD VA I01 BX002715BLRD VA I01 BX002906NHLBI NIH HHS R01 HL056067NHLBI NIH HHS R01 HL095791NHLBI NIH HHS R01 HL118979NHLBI NIH HHS R37 HL056067NIAID NIH HHS R01 AI034495NIAID NIH HHS R37 AI034495NIAID NIH HHS R56 AI116715NIAID NIH HHS U19 AI051731NIDDK NIH HHS R01 DK044319NIEHS NIH HHS P30 ES005605
6 · The paper itself

Abstract

Helminths stimulate the secretion of Th2 cytokines, like IL-4, and suppress lethal graft-versus-host disease (GVHD) after bone marrow transplantation. This suppression depends on the production of immune-modulatory TGF-β and is associated with TGF-β-dependent in vivo expansion of Foxp3

Indexed as

AnimalsBone Marrow TransplantationCD4-Positive T-LymphocytesGATA3 Transcription FactorGraft vs Host DiseaseInterleukin-4Lymphocyte ActivationMaleMiceMice, Inbred BALB CMice, Inbred C57BLNematospiroides dubiusStrongylida InfectionsT-Lymphocytes, RegulatoryTransforming Growth Factor betaGata3 protein, mouseGATA3 Transcription FactorInterleukin-4Transforming Growth Factor beta

Identifiers

PMID30291167
PMCPMC6219912
OpenAlexW2895230890

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.