Evidence map›Paper›PMID 30291166›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2018

IL-4 and IL-13 Guide Early Thymic Progenitors To Mature toward Dendritic Cells.

Subhasis Barik, Alexis N Cattin-Roy, Mindy M Miller, Tobechukwu K Ukah, Habib Zaghouani

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Frontiers in cell and developmental biology · 2022
    Article
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Subhasis BarikDepartment of Molecular Microbiology and Immunology, University of Missouri School of Medicine, Columbia, MO 65212.
Alexis N Cattin-RoyDepartment of Molecular Microbiology and Immunology, University of Missouri School of Medicine, Columbia, MO 65212.
Mindy M MillerDepartment of Molecular Microbiology and Immunology, University of Missouri School of Medicine, Columbia, MO 65212.
Tobechukwu K UkahDepartment of Molecular Microbiology and Immunology, University of Missouri School of Medicine, Columbia, MO 65212.
Habib ZaghouaniDepartment of Molecular Microbiology and Immunology, University of Missouri School of Medicine, Columbia, MO 65212; zaghouanih@health.missouri.edu.ORCID 0000-0003-4653-0050
University of Missouri · USUniversity of Missouri Health System · US

Funding

MOLECULAR BASIS OF GENE EXPRESSION AND SIGNAL PROCESSINGT32GM008396 · NIGMS · UNIVERSITY OF MISSOURI-COLUMBIA · PI HANNINK, MARK · 1991 to 2021
$4.1M
Regulation of Autoimmune EncephalomyelitisR01NS057194 · NINDS · UNIVERSITY OF MISSOURI-COLUMBIA · PI ZAGHOUANI, HABIB · 2008 to 2017
$2.9M
NIGMS NIH HHS T32 GM008396NINDS NIH HHS R01 NS057194
6 · The paper itself

Abstract

Recently we reported that IL-4 and IL-13 signaling in murine early thymic progenitors (ETPs) expressing the heteroreceptor (HR) comprising IL-4 receptor α (IL-4Rα) and IL-13 receptor α 1 (IL-13Rα1) activate STAT6 and inhibit ETP maturation potential toward T cells. In this study, we asked whether IL-4 and IL-13 signaling through the HR mobilizes other STAT molecules to shape ETP fate decision. The findings indicate that HR

Indexed as

AnimalsCell DifferentiationCentral ToleranceDendritic CellsFemaleInterferon Regulatory Factor-8Interferon Regulatory FactorsInterleukin-13Interleukin-4MiceMice, KnockoutSTAT1 Transcription FactorSTAT6 Transcription FactorThymocytesInterferon Regulatory Factor-8Interferon Regulatory FactorsInterleukin-13Interleukin-4Stat1 protein, mouseSTAT1 Transcription FactorStat6 protein, mouseSTAT6 Transcription Factor

Identifiers

PMID30291166
PMCPMC6219934
OpenAlexW2895445160

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.