Evidence map›Paper›PMID 30291162›Full record

ArticleDevelopment (Cambridge, England)2018

Inhibition of cell fate repressors secures the differentiation of the touch receptor neurons of

Chaogu Zheng, Felix Qiaochu Jin, Brian Loeber Trippe, Ji Wu, Martin Chalfie

Open access · bronzeAbstract read
In one paragraph

Article in Development (Cambridge, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. IndividualLife science alliance · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Transcriptional regulation of neuronal identity.The European journal of neuroscience · 2022
    Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Chaogu ZhengDepartment of Biological Sciences, Columbia University, New York, NY 10027, USA.ORCID 0000-0002-5048-4520
Felix Qiaochu JinDepartment of Biological Sciences, Columbia University, New York, NY 10027, USA.
Brian Loeber TrippeDepartment of Biological Sciences, Columbia University, New York, NY 10027, USA.
Ji WuDepartment of Biological Sciences, Columbia University, New York, NY 10027, USA.
Martin ChalfieDepartment of Biological Sciences, Columbia University, New York, NY 10027, USA mc21@columbia.edu.ORCID 0000-0002-9079-7046
Columbia University · US

Funding

GENETIC ANALYSIS OF NEMATODE CELL DIFFERENTIATIONR01GM030997 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI CHALFIE, MARTIN · 1985 to 2017
$7.1M
GENETIC ANALYSIS OF NEMATODE CELL DIFFERENTIATIONR37GM030997 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI CHALFIE, MARTIN · 1999 to 2009
$6.6M
Genetic analysis of nematode cell differentiationR35GM122522 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI MARTIN CHALFIE · 2017 to 2026
$6.5M
NIGMS NIH HHS R01 GM030997NIGMS NIH HHS R35 GM122522NIGMS NIH HHS R37 GM030997
6 · The paper itself

Abstract

Terminal differentiation generates the specialized features and functions that allow postmitotic cells to acquire their distinguishing characteristics. This process is thought to be controlled by transcription factors called 'terminal selectors' that directly activate a set of downstream effector genes. In

Indexed as

Cell DifferentiationCell LineageAnimalsBase SequenceBiomarkersCaenorhabditis elegansCaenorhabditis elegans ProteinsGene Expression Regulation, DevelopmentalModels, BiologicalMutationNeuronsPenetranceReceptors, Cell SurfaceRNA InterferenceTime FactorsTouchBiomarkersCaenorhabditis elegans ProteinsReceptors, Cell SurfaceTranscription FactorsBinary decisionCell fateNeuronal differentiationRepressorsTouch receptor neuronsZEB

Identifiers

PMID30291162
PMCPMC6262790
OpenAlexW2891089679

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.