ArticleThe Journal of experimental medicine2018
Kinetics of adult hematopoietic stem cell differentiation in vivo.
Article in The Journal of experimental medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed.
- Clonal memory of cell division in humans diverges between healthy haematopoiesis and acute myeloid leukaemia.Nature communications · 2026Article
- T cell development from expanded hematopoietic progenitors reveals initiation control byScience immunology · 2026Article
- Lineage tracing of both quiescent G0 and active Hoxb5+ LT-HSCs that actively contribute to homeostatic mouse hematopoiesis.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Immature monocytic cells within tumors differentiate into immunosuppressive cells in resistant tumors to immunotherapy.iScience · 2025Article
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- Direct megakaryopoiesis.Current opinion in hematology · 2025Review
- Leukemogenic Kras mutation reprograms multipotent progenitors to facilitate its spread through the hematopoietic system.The Journal of experimental medicine · 2025Article
- Review
- Dynamically adjusted cell fate decisions and resilience to mutant invasion during steady-state hematopoiesis revealed by an experimentally parameterized mathematical model.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- G2 arrest primes hematopoietic stem cells for megakaryopoiesis.Cell reports · 2024Article
- Review
- A time- and single-cell-resolved model of murine bone marrow hematopoiesis.Cell stem cell · 2024Article
- Multimodal cartography of human lymphopoiesis reveals B and T/NK/ILC lineages are subjected to differential regulation.iScience · 2023Article
- Murine erythroid differentiation kinetics in vivo under normal and anemic stress conditions.Blood advances · 2023Article
- Article
- Stem cell decoupling underlies impaired lymphoid development during aging.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Kinetics of blood cell differentiation during hematopoiesis revealed by quantitative long-term live imaging.eLife · 2023Article
- HSC-independent definitive hematopoiesis persists into adult life.Cell reports · 2023Article
- Multi-lineage Differentiation from Hematopoietic Stem Cells.Advances in experimental medicine and biology · 2023Review
- Fate mapping of hematopoietic stem cells reveals two pathways of native thrombopoiesis.Nature communications · 2022Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Adult hematopoiesis has been studied in terms of progenitor differentiation potentials, whereas its kinetics in vivo is poorly understood. We combined inducible lineage tracing of endogenous adult hematopoietic stem cells (HSCs) with flow cytometry and single-cell RNA sequencing to characterize early steps of hematopoietic differentiation in the steady-state. Labeled cells, comprising primarily long-term HSCs and some short-term HSCs, produced megakaryocytic lineage progeny within 1 wk in a process that required only two to three cell divisions. Erythroid and myeloid progeny emerged simultaneously by 2 wk and included a progenitor population with expression features of both lineages. Myeloid progenitors at this stage showed diversification into granulocytic, monocytic, and dendritic cell types, and rare intermediate cell states could be detected. In contrast, lymphoid differentiation was virtually absent within the first 3 wk of tracing. These results show that continuous differentiation of HSCs rapidly produces major hematopoietic lineages and cell types and reveal fundamental kinetic differences between megakaryocytic, erythroid, myeloid, and lymphoid differentiation.
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