Evidence map›Paper›PMID 30291144›Full record

ArticleThe Journal of biological chemistry2018

A dominant dendrite phenotype caused by the disease-associated G253D mutation in doublecortin (DCX) is not due to its endocytosis defect.

Chan Choo Yap, Laura Digilio, Kamil Kruczek, Matylda Roszkowska, Xiao-Qin Fu, Judy S Liu, Bettina Winckler

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 5 countries.

Chan Choo YapFrom the Department of Cell Biology, University of Virginia, Charlottesville, Virginia 22908.
Laura DigilioFrom the Department of Cell Biology, University of Virginia, Charlottesville, Virginia 22908.
Kamil Kruczekthe Program in Biotechnology and.
Matylda Roszkowskathe Faculty of Biology and Earth Sciences, Jagiellonian University, 31-007 Cracow, Poland, and.
Xiao-Qin Futhe Department of Neurology, Brown University, Providence, Rhode Island 02912.
Judy S Liuthe Department of Neurology, Brown University, Providence, Rhode Island 02912.
Bettina WincklerFrom the Department of Cell Biology, University of Virginia, Charlottesville, Virginia 22908, BWinckler@virginia.edu.ORCID 0000-0002-7924-9313
University of Virginia · USBrown University · USJagiellonian University · PL

Funding

Multifunctional roles for doublecortin (DCX)in neural developmentR01NS081674 · NINDS · UNIVERSITY OF VIRGINIA · PI WINCKLER, BETTINA R · 2013 to 2017
$1.7M
NINDS NIH HHS R01 NS081674
6 · The paper itself

Abstract

Doublecortin (DCX) is a protein needed for cortical development, and

Indexed as

Adaptor Protein Complex 2AnimalsBinding SitesCell Adhesion MoleculesChlorocebus aethiopsCOS CellsDendritesDoublecortin Domain ProteinsDoublecortin ProteinEndocytosisHEK293 CellsHumansMiceMicrotubule-Associated ProteinsMutationNerve Growth FactorsAdaptor Protein Complex 2Cell Adhesion MoleculesDCX protein, humanDcx protein, mouseDcx protein, ratDoublecortin Domain ProteinsDoublecortin ProteinMicrotubule-Associated ProteinsNerve Growth FactorsNeuropeptidesNFASC protein, humanaxon initial segmentclathrinclathrin adaptordendritedominant allele of DCXendocytosislissencephalymicrotubulemultifunctional proteinneurite outgrowthneurofascinneuron

Identifiers

PMID30291144
PMCPMC6295730
OpenAlexW2895900335

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.