ArticleImmunity2018
Secreted IgD Amplifies Humoral T Helper 2 Cell Responses by Binding Basophils via Galectin-9 and CD44.
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Article in Immunity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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51citing papers in PubMed
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51 citing papers in PubMed, 102 citations in OpenAlex.
- Sustained successful peanut oral immunotherapy associated with low basophil activation and peanut-specific IgE.The Journal of allergy and clinical immunology · 2020Trial
- Mechanisms of IgE-mediated food allergy and the role of allergen-specific B cells.FEBS letters · 2026Review
- Modulating the Allergen-Specific Immune Response to Achieve Remission of Food Allergy Through Oral Immunotherapy.Advances in experimental medicine and biology · 2026Review
- The Major Role of Type 2 Inflammation in Asthma: From the Perspective of Immunological Mechanism.BioMed research international · 2026Review
- Immunoglobulin M regulates airway hyperresponsiveness independent of T helper 2 allergic inflammation.eLife · 2025Article
- Anti-IgD nanobodies as novel tools for studying human IgD biology.Scientific reports · 2025Article
- The Crystal Structure of Human IgD-Fc Reveals Unexpected Differences With Other Antibody Isotypes.Proteins · 2025Article
- Type 2 immunity in allergic diseases.Cellular & molecular immunology · 2025Review
- Article
- CCR7A defines a subpopulation of IgDFrontiers in immunology · 2025Article
- IgT and IgD dominance in the teleost central nervous system.Frontiers in immunology · 2025Article
- Correlation between dietary calcium intake and eczema in American adult population.Scientific reports · 2024Article
- Interleukin-33-activated basophils promote asthma by regulating Th2 cell entry into lung tissue.The Journal of experimental medicine · 2024Article
- MGAT4A/Galectin9-Driven N-Glycosylation Aberration as a Promoting Mechanism for Poor Prognosis of Endometrial Cancer with TP53 Mutation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- A Comprehensive Review on Porcine Reproductive and Respiratory Syndrome Virus with Emphasis on Immunity.Vaccines · 2024Review
- Implications of PD-L1 expression on the immune microenvironment in HER2-positive gastric cancer.Molecular cancer · 2024Article
- Immunoglobulin class-switch recombination: Mechanism, regulation, and related diseases.MedComm · 2024Review
- IgDPathogens (Basel, Switzerland) · 2024Article
- The ontogenesis and heterogeneity of basophils.Discovery immunology · 2024Review
- Immune cell dynamics and the impact on the efficiency of transvascular antitumor interventional therapies in hepatocellular carcinoma patients.Frontiers in immunology · 2024Observational
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Authors and funding
25 authors at 8 institutions in 4 countries.
Meimei ShanDepartment of Medicine, Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Mucosal Immunology Studies Team (MIST), National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20982, USA.
Jorge CarrilloDepartment of Medicine, Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Institut de Recerca de la SIDA-IrsiCaixa-HIVACAT, IGTP, UAB, 08916 Badalona, Barcelona, Spain.
Ada YesteProgram for Inflammatory and Cardiovascular Disorders, Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), 08003 Barcelona, Spain.
Cindy GutzeitDepartment of Medicine, Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Daniel Segura-GarzónProgram for Inflammatory and Cardiovascular Disorders, Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), 08003 Barcelona, Spain.
A Cooper WallandDepartment of Medicine, Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Marc PybusProgram for Inflammatory and Cardiovascular Disorders, Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), 08003 Barcelona, Spain.
Emilie K GrassetDepartment of Medicine, Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Medicine, Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital, 171 77 Stockholm, Sweden.
John R YeiserDepartment of Medicine, Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Dean B MatthewsDepartment of Medicine, Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Willem van de VeenSwiss Institute of Allergy and Asthma Research, University of Zurich, Christine-Kühne Research Center for Allergy and Education, 7270 Davos, Switzerland.
Laura ComermaProgram for Inflammatory and Cardiovascular Disorders, Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), 08003 Barcelona, Spain.
Bing HeDepartment of Medicine, Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Tadech BoonpiyathadSwiss Institute of Allergy and Asthma Research, University of Zurich, Christine-Kühne Research Center for Allergy and Education, 7270 Davos, Switzerland.
Haekyung LeeDepartment of Medicine, Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Julià BlancoInstitut de Recerca de la SIDA-IrsiCaixa-HIVACAT, IGTP, UAB, 08916 Badalona, Barcelona, Spain; University of Vic, UVIC-UCC, 08500 Vic, Barcelona, Spain.
Lisa C OsborneDepartment of Medicine, Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Medical College of Cornell University, New York, NY 10021, USA.
Mark C SiracusaDepartment of Medicine, Center for Immunity and Inflammation, Rutgers New Jersey Medical School, Newark, NJ 07103, USA.
Mübeccel AkdisSwiss Institute of Allergy and Asthma Research, University of Zurich, Christine-Kühne Research Center for Allergy and Education, 7270 Davos, Switzerland.
David ArtisMucosal Immunology Studies Team (MIST), National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20982, USA; Department of Medicine, Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Medical College of Cornell University, New York, NY 10021, USA.
Saurabh MehandruDepartment of Medicine, Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Gastroenterology, Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Hugh A SampsonDivision of Pediatric Allergy and Immunology, Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
M Cecilia BerinDivision of Pediatric Allergy and Immunology, Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Kang ChenMucosal Immunology Studies Team (MIST), National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20982, USA; Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI 48201, USA.
Andrea CeruttiDepartment of Medicine, Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Mucosal Immunology Studies Team (MIST), National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20982, USA; Program for Inflammatory and Cardiovascular Disorders, Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), 08003 Barcelona, Spain; Catalan Institute for Research and Advanced Studies (ICREA), 08003 Barcelona, Spain. Electronic address: acerutti@imim.es.
Icahn School of Medicine at Mount Sinai · USHospital del Mar Research Institute · ESNational Institutes of Health · USUniversity of Zurich · CHIrsiCaixa · ESCornell University · USKarolinska University Hospital · SERutgers, The State University of New Jersey · US
Funding
Regulation of IgA class switching in the intestinal mucosaP01AI061093 · NIAID · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI CUNNINGHAM-RUNDLES, CHARLOTTE · 2004 to 2021
$29.8MHuman MAIT celis in airway mucosal immune responses to intracellular infectionsU01AI095776 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI LEWINSOHN, DAVID M. · 2011 to 2015
$8.9MRegulation of antibody production by innate signalsR01AI057653 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI CERUTTI, ANDREA · 2005 to 2016
$4.3MRegulation and Function of Immunoglobulin D in Mucosal Immune DefenseU01AI095613 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CERUTTI, ANDREA · 2011 to 2015
$2.1MThe impact of HIV-1 infection and its treatment on gastrointestinal B cellsR01DK112296 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MEHANDRU, SAURABH · 2017 to 2021
$2.0MMechanism of Humoral Immune Defects in Autoimmune Polyglandular Syndrome Type 1R21AI122256 · NIAID · WAYNE STATE UNIVERSITY · PI CHEN, KANG · 2016 to 2017
$419kNIAID NIH HHS P01 AI061093NIAID NIH HHS R01 AI057653NIAID NIH HHS U01 AI095613NIAID NIH HHS U01 AI095776NIDDK NIH HHS R01 DK112296
Abstract
B cells thwart antigenic aggressions by releasing immunoglobulin M (IgM), IgG, IgA, and IgE, which deploy well-understood effector functions. In contrast, the role of secreted IgD remains mysterious. We found that some B cells generated IgD-secreting plasma cells following early exposure to external soluble antigens such as food proteins. Secreted IgD targeted basophils by interacting with the CD44-binding protein galectin-9. When engaged by antigen, basophil-bound IgD increased basophil secretion of interleukin-4 (IL-4), IL-5, and IL-13, which facilitated the generation of T follicular helper type 2 cells expressing IL-4. These germinal center T cells enhanced IgG1 and IgE but not IgG2a and IgG2b responses to the antigen initially recognized by basophil-bound IgD. In addition, IgD ligation by antigen attenuated allergic basophil degranulation induced by IgE co-ligation. Thus, IgD may link B cells with basophils to optimize humoral T helper type 2-mediated immunity against common environmental soluble antigens.
Indexed as
AnimalsBasophilsCell Line, TumorCells, CulturedGalectinsGene Expression ProfilingHumansHyaluronan ReceptorsImmunoglobulin DImmunoglobulin EImmunoglobulin GInterleukin-4Mice, Inbred BALB CProtein BindingTh2 CellsGalectinsHyaluronan ReceptorsImmunoglobulin DImmunoglobulin EImmunoglobulin GInterleukin-4LGALS9 protein, humanallergyantibodybasophilB cellCD44galectinhumoral immunityIgDmucosal immunityTh2
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