ArticleGenome biology2018
Modularity of genes involved in local adaptation to climate despite physical linkage.
Article in Genome biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 58 citations in OpenAlex.
- Haplotype structure: an overlooked key factor shaping the genomic selection response.Genetics · 2026Article
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- Climate-Driven Niche Tracking and Genomic Resilience Shape Future Distribution of a Widespread Agricultural Weed.Molecular ecology · 2026Article
- Pleiotropy and Facilitation of Local Adaptation in the Silverleaf Sunflower Helianthus argophyllus.Genome biology and evolution · 2026Article
- Identifying the Degree of Gene Reuse During Repeated Adaptation.Molecular ecology · 2025Review
- Local adaptation of both plant and pathogen: an arms-race compromise in switchgrass rust.The New phytologist · 2025Article
- Integrating population genomics and environmental data to predict adaptation to climate change in post-bottleneck Tibetan macaques.Science advances · 2025Article
- Latitudinal Clines in Climate and Sleep Patterns Shape Disease Outcomes inEcology and evolution · 2025Article
- Local adaptation and future climate vulnerability in a wild rodent.Nature communications · 2023Article
- The paradox of adaptive trait clines with nonclinal patterns in the underlying genes.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- The ensemble of gene regulatory networks at mutation-selection balance.Journal of the Royal Society, Interface · 2023Article
- Genomic analyses point to a low evolutionary potential of prospective source populations for assisted migration in a forest herb.Evolutionary applications · 2022Article
- The influence of genetic architecture on responses to selection under drought in rice.Evolutionary applications · 2022Article
- Chasing genetic correlation breakers to stimulate population resilience to climate change.Scientific reports · 2022Article
- Reduced olfactory acuity in recently flightless insects suggests rapid regressive evolution.BMC ecology and evolution · 2022Article
- Article
- Novel and emerging biotechnological crop protection approaches.Plant biotechnology journal · 2021Review
- Temperature, rainfall and wind variables underlie environmental adaptation in natural populations of Drosophila melanogaster.Molecular ecology · 2021Article
- Article
- Protocol for Projecting Allele Frequency Change under Future Climate Change at Adaptive-Associated Loci.STAR protocols · 2020Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLinkage among genes experiencing different selection pressures can make natural selection less efficient. Theory predicts that when local adaptation is driven by complex and non-covarying stresses, increased linkage is favored for alleles with similar pleiotropic effects, with increased recombination favored among alleles with contrasting pleiotropic effects. Here, we introduce a framework to test these predictions with a co-association network analysis, which clusters loci based on differing associations. We use this framework to study the genetic architecture of local adaptation to climate in lodgepole pine, Pinus contorta, based on associations with environments.
resultsWe identify many clusters of candidate genes and SNPs associated with distinct environments, including aspects of aridity and freezing, and discover low recombination rates among some candidate genes in different clusters. Only a few genes contain SNPs with effects on more than one distinct aspect of climate. There is limited correspondence between co-association networks and gene regulatory networks. We further show how associations with environmental principal components can lead to misinterpretation. Finally, simulations illustrate both benefits and caveats of co-association networks.
conclusionsOur results support the prediction that different selection pressures favor the evolution of distinct groups of genes, each associating with a different aspect of climate. But our results went against the prediction that loci experiencing different sources of selection would have high recombination among them. These results give new insight into evolutionary debates about the extent of modularity, pleiotropy, and linkage in the evolution of genetic architectures.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.