SynthesisMedicine2018
Role of qSOFA in predicting mortality of pneumonia: A systematic review and meta-analysis.
Synthesis in Medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Position Paper for the State-of-the-Art Application of Respiratory Support in Patients with COVID-19.Respiration; international review of thoracic diseases · 2020Guideline
- Epidemiology, risk factors and clinical outcome of community-acquired pneumonia in severely immunosuppressed patients: a comprehensive analysis from the multinational, prospective CAPNETZ Cohort.ERJ open research · 2026Article
- Predictors of high-flow nasal cannula (HFNC) failure in severe community-acquired pneumonia or COVID-19.Internal and emergency medicine · 2025Article
- Comparative Effectiveness of CURB-65 and qSOFA Scores in Predicting Pneumonia Outcomes: A Systematic Review.Cureus · 2024Review
- Comparison of modified quick Sequential Organ Failure Assessment models as triage tools for febrile patients.Clinical and experimental emergency medicine · 2024Article
- Species Distribution, Typical Clinical Features and Risk Factors for Poor Prognosis of Super-Elderly Patients with Bloodstream Infection in China.Infection and drug resistance · 2024Article
- Article
- Apyrexia improves the prognostic value of quick SOFA in older patients with acute pneumonia or bacteremic urinary tract infection.Infection · 2023Article
- Performance of point-of-care severity scores to predict prognosis in patients admitted through the emergency department with COVID-19.Journal of hospital medicine · 2023Article
- Validation of the qSOFA and CRB-65 in SARS-CoV-2-infected community-acquired pneumonia.ERJ open research · 2023Article
- Combining C-reactive protein and quick sequential organ failure assessment (qSOFA) to improve prognostic accuracy for sepsis and mortality in adult inpatients: A systematic review.Health science reports · 2023Article
- Neurofilament light chain levels predict encephalopathy and outcome in community-acquired pneumonia.Annals of clinical and translational neurology · 2023Observational
- Unmet needs in pneumonia research: a comprehensive approach by the CAPNETZ study group.Respiratory research · 2022Review
- qSOFA score poorly predicts critical progression in COVID-19 patients.Wiener medizinische Wochenschrift (1946) · 2022Article
- The effectiveness of the sarcopenia index in predicting septic shock and death in elderly patients with community-acquired pneumonia.BMC geriatrics · 2022Article
- Septic patients without obvious signs of infection at baseline are more likely to die in the ICU.BMC infectious diseases · 2022Observational
- Understanding the Host in the Management of Pneumonia. An Official American Thoracic Society Workshop Report.Annals of the American Thoracic Society · 2021Article
- Anakinra after treatment with corticosteroids alone or with tocilizumab in patients with severe COVID-19 pneumonia and moderate hyperinflammation. A retrospective cohort study.Internal and emergency medicine · 2021Observational
- Challenges in developing a consensus definition of neonatal sepsis.Pediatric research · 2020Review
- [Position Paper for the State of the Art Application of Respiratory Support in Patients with COVID-19 - German Respiratory Society].Pneumologie (Stuttgart, Germany) · 2020Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe concept of sepsis was redefined recently, and a new screening system termed the quick Sequential Organ Failure Assessment (qSOFA) was recommended for identifying infected patients at high risk for death. However, the predictive value of qSOFA for mortality in patients with pneumonia remains unclear. Thus, we performed a meta-analysis with the aim of determining the prognostic value of qSOFA in predicting mortality in patients with pneumonia.
methodsEmbase, Google Scholar, and PubMed (up to March 2018) were searched for related articles. We constructed a 2 × 2 contingency table according to mortality and qSOFA scores (<2 and ≥2) in patients with pneumonia. Two investigators independently extracted data and assessed study eligibility. A bivariate meta-analysis model was used to determine the prognostic value of qSOFA in predicting mortality. I index and Q-test were used to assess heterogeneity.
resultsSix studies with 17,868 patients were included. A qSOFA score ≥2 was related to a higher risk for death in patients with pneumonia, with a pooled risk ratio (RR) was 3.35 (95% CI, 2.24-5.01) using a random-effects model (I = 89.4%). The pooled sensitivity and specificity of a qSOFA score ≥2 to predict mortality in patients with pneumonia were 0.43 (95% CI, 0.33-0.53) and 0.86 (95% CI, 0.76-0.92), respectively. The diagnostic OR was 4 (95% CI, 3-6). The area under the summary receiver operator characteristic (SROC) curve was 0.67 (95% CI, 0.63-0.71). When we calculated the community-acquired pneumonia (CAP) subgroup, the pooled sensitivity and specificity were 0.36 (95% CI, 0.26-0.48) and 0.91 (95% CI, 0.84-0.95), respectively. The area under the SROC curve was 0.70 (95% CI, 0.66-0.74).
conclusionsA qSOFA score ≥2 is strongly associated with mortality in patients with pneumonia, but the poor sensitivity of qSOFA may have limitations in the early identification of mortality in patients with pneumonia.
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