Evidence map›Paper›PMID 30289750›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2019

Deletion in mice of X-linked, Brugada syndrome- and atrial fibrillation-associated Kcne5 augments ventricular K

Jens-Peter David, Ulrike Lisewski, Shawn M Crump, Thomas A Jepps, Elke Bocksteins, Nicola Wilck, Janine Lossie, Torsten K Roepke, Nicole Schmitt, Geoffrey W Abbott

Open access · greenAbstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
  2. Review
  3. Roles of funny HCN.Comparative biochemistry and physiology. Toxicology & pharmacology : CBP · 2025
    Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. Review
  9. Review
  10. Review
  11. Inactivation of Native K Channels.The Journal of membrane biology · 2022
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Open life sciences · 2021
    Article
  18. Review
  19. Review
  20. Brugada Syndrome: Oligogenic or Mendelian Disease?International journal of molecular sciences · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 4 countries.

Jens-Peter DavidDanish National Research Foundation Centre for Cardiac Arrhythmia, University of Copenhagen, Copenhagen, Denmark.
Ulrike LisewskiMedical Clinic and Polyclinic for Cardiology and Angiology, Charité Medical University of Berlin, Berlin, Germany.
Shawn M CrumpBioelectricity Laboratory, Department of Physiology and Biophysics, University of California, Irvine, Irvine, California, USA; and.
Thomas A JeppsDanish National Research Foundation Centre for Cardiac Arrhythmia, University of Copenhagen, Copenhagen, Denmark.
Elke BocksteinsLaboratory for Molecular Biophysics, Physiology, and Pharmacology, Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.
Nicola WilckMedical Clinic and Polyclinic for Cardiology and Angiology, Charité Medical University of Berlin, Berlin, Germany.
Janine LossieMedical Clinic and Polyclinic for Cardiology and Angiology, Charité Medical University of Berlin, Berlin, Germany.
Torsten K RoepkeMedical Clinic and Polyclinic for Cardiology and Angiology, Charité Medical University of Berlin, Berlin, Germany.
Nicole SchmittDanish National Research Foundation Centre for Cardiac Arrhythmia, University of Copenhagen, Copenhagen, Denmark.
Geoffrey W AbbottBioelectricity Laboratory, Department of Physiology and Biophysics, University of California, Irvine, Irvine, California, USA; and.
Charité - Universitätsmedizin Berlin · DEDanish National Research Foundation · DKUniversity of Copenhagen · DKUniversity of Antwerp · BEUniversity of California, Irvine · US

Funding

K+ channel trafficking and modulation in MinK and MiRP1R01HL079275 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI ABBOTT, GEOFFREY W · 2005 to 2015
$4.6M
NHLBI NIH HHS R01 HL079275
6 · The paper itself

Abstract

KCNE5 is an X-linked gene encoding KCNE5, an ancillary subunit to voltage-gated potassium (K

Indexed as

Genes, X-LinkedIon Channel GatingAnimalsAtrial FibrillationBrugada SyndromeCells, CulturedFemaleHEK293 CellsHumansMaleMiceMice, Inbred C57BLMice, KnockoutMyocytes, CardiacPotassiumPotassium Channels, Voltage-GatedKCNE5 protein, humanPotassiumPotassium Channels, Voltage-GatedMiRP4potassium channel

Identifiers

PMID30289750
PMCPMC6338634
OpenAlexW2894582260

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.