Evidence map›Paper›PMID 30289352›Full record

ArticleVirulence2018

Galleria mellonella experimental model for bat fungal pathogen Pseudogymnoascus destructans and human fungal pathogen Pseudogymnoascus pannorum.

Beth Burgwyn Fuchs, Sudha Chaturvedi, Rodnei Dennis Rossoni, Patricia P de Barros, Fernando Torres-Velez, Eleftherios Mylonakis, Vishnu Chaturvedi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virulence, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Microbiology spectrum · 2025
    Article
  2. Characterization of the Growth and Morphology of a BSL-2Journal of fungi (Basel, Switzerland) · 2022
    Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Beth Burgwyn Fuchsa Division of Infectious Diseases, Rhode Island Hospital , Warren Alpert Medical School at Brown University , Providence , RI , USA.
Sudha Chaturvedib Mycology Laboratory, Division of Infectious Diseases , Wadsworth Center, New York State Department of Health , Albany , NY , USA.
Rodnei Dennis Rossonid Department of Biosciences and Oral Diagnosis, Institute of Science and Technology , UNESP - Univ Estadual Paulista , Sao Jose dos Campos , Brazil.ORCID 0000-0002-9977-3040
Patricia P de Barrosd Department of Biosciences and Oral Diagnosis, Institute of Science and Technology , UNESP - Univ Estadual Paulista , Sao Jose dos Campos , Brazil.
Fernando Torres-Veleze Division of Infectious Diseases , Wadsworth Center, New York State Department of Health , Albany , NY , USA.
Eleftherios Mylonakisa Division of Infectious Diseases, Rhode Island Hospital , Warren Alpert Medical School at Brown University , Providence , RI , USA.
Vishnu Chaturvedib Mycology Laboratory, Division of Infectious Diseases , Wadsworth Center, New York State Department of Health , Albany , NY , USA.ORCID 0000-0002-3922-9676
New York State Department of Health · USBrown University · USUniversidade Estadual Paulista (Unesp) · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Laboratory investigations of the pathogenesis of Pseudogymnoascus destructans, the fungal causal agent of bat White Nose Syndrome (WNS), presents unique challenges due to its growth requirements (4°-15°C) and a lack of infectivity in the current disease models. Pseudogymnoascus pannorum is the nearest fungal relative of P. destructans with wider psychrophilic - physiological growth range, and ability to cause rare skin infections in humans. Our broad objectives are to create the molecular toolkit for comparative study of P. destructans and P. pannorum pathogenesis. Towards these goals, we report the successful development of an invertebrate model in the greater wax moth Galleria mellonella. Both P. destructans and P. pannorum caused fatal disease in G. mellonella and elicited immune responses and histopathological changes consistent with the experimental disease.

Indexed as

Disease Models, AnimalAnimalsAscomycotaChiropteraHumansMothsMycosesNosePhylogenyGalleria mellonellahistopathologyinfection modelinvertebrate hostPseudogymnoascus destructansPseudogymnoascus pannorumsurvival curve

Identifiers

PMID30289352
PMCPMC6177250
OpenAlexW2895330695

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.