Evidence map›Paper›PMID 30288759›Full record

ReviewJPEN. Journal of parenteral and enteral nutrition2019

Hypoalbuminemia: Pathogenesis and Clinical Significance.

Peter B Soeters, Robert R Wolfe, Alan Shenkin

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in JPEN. Journal of parenteral and enteral nutrition, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 829 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
829citing papers in PubMed, 5 pooled it
54.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

829 citing papers in PubMed, 5 syntheses or guidelines pooled it, 1,234 citations in OpenAlex.

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769 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 3 countries.

Peter B SoetersDepartment of Surgery, Maastricht University Medical Center, Maastricht, Netherlands.
Robert R WolfeDepartment of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Alan ShenkinDepartment of Clinical Chemistry, University of Liverpool, Liverpool, UK.
Maastricht University Medical Centre · NLUniversity of Arkansas for Medical Sciences · USUniversity of Liverpool · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypoalbuminemia is associated with inflammation. Despite being addressed repeatedly in the literature, there is still confusion regarding its pathogenesis and clinical significance. Inflammation increases capillary permeability and escape of serum albumin, leading to expansion of interstitial space and increasing the distribution volume of albumin. The half-life of albumin has been shown to shorten, decreasing total albumin mass. These 2 factors lead to hypoalbuminemia despite increased fractional synthesis rates in plasma. Hypoalbuminemia, therefore, results from and reflects the inflammatory state, which interferes with adequate responses to events like surgery or chemotherapy, and is associated with poor quality of life and reduced longevity. Increasing or decreasing serum albumin levels are adequate indicators, respectively, of improvement or deterioration of the clinical state. In the interstitium, albumin acts as the main extracellular scavenger, antioxidative agent, and as supplier of amino acids for cell and matrix synthesis. Albumin infusion has not been shown to diminish fluid requirements, infection rates, and mortality in the intensive care unit, which may imply that there is no body deficit or that the quality of albumin "from the shelf" is unsuitable to play scavenging and antioxidative roles. Management of hypoalbuminaemia should be based on correcting the causes of ongoing inflammation rather than infusion of albumin. After the age of 30 years, muscle mass and function slowly decrease, but this loss is accelerated by comorbidity and associated with decreasing serum albumin levels. Nutrition support cannot fully prevent, but slows down, this chain of events, especially when combined with physical exercise.

Indexed as

Capillary PermeabilityHumansHypoalbuminemiaInflammationalbumin infusionalbumin massalbumin scavengercapillary permeabilityfractional synthesis rate albumingrowthhypoalbuminemiaimmune responseinflammationinterstitial spacepregnancypubertyserum albumin binding proteinserum albumin indicator of inflammatory activityserum albumin risk factorvascular endothelial growth factor

Identifiers

PMID30288759
PMCPMC7379941
OpenAlexW2895009116

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.