Evidence map›Paper›PMID 30288635›Full record

ArticleInflammation2019

Alveolar Macrophage Chemokine Secretion Mediates Neutrophilic Lung Injury in Nox2-Deficient Mice.

Renee M Potera, Mou Cao, Lin F Jordan, Richard T Hogg, Jessica S Hook, Jessica G Moreland

Open access · greenAbstract read
In one paragraph

Article in Inflammation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 19 citations in OpenAlex.

  1. Myeloid TLR2 signaling amplifies immunopathology in influenza-infected murine neonates.American journal of respiratory cell and molecular biology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Renee M PoteraDepartment of Pediatrics, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX, 75390-9063, USA. Renee.Potera@UTSouthwestern.edu.ORCID http://orcid.org/0000-0003-3484-0318
Mou CaoDepartment of Pediatrics, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX, 75390-9063, USA.
Lin F JordanDepartment of Pediatrics, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX, 75390-9063, USA.
Richard T HoggDepartment of Pediatrics, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX, 75390-9063, USA.
Jessica S HookDepartment of Pediatrics, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX, 75390-9063, USA.
Jessica G MorelandDepartment of Pediatrics, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX, 75390-9063, USA.
The University of Texas Southwestern Medical Center · USSouthwestern Medical Center · US

Funding

ANTECEDANTS SEQUELAE OF CHILDHOOD ONSET DISEASEK12HD068369 · NICHD · UT SOUTHWESTERN MEDICAL CENTER · PI SKAPEK, STEPHEN X · 2011 to 2020
$3.0M
A novel anti-inflammatory role for the neutrophil NADPH oxidaseR21AI109127 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI MORELAND, JESSICA G · 2014 to 2015
$437k
National Institute of Child Health and Human Development 5 K12 HD-068369-05NIAID NIH HHS R21 AI109127NICHD NIH HHS K12 HD068369NIH HHS 1R21 AI109127-01
6 · The paper itself

Abstract

Acute lung injury (ALI), developing as a component of the systemic inflammatory response syndrome (SIRS), leads to significant morbidity and mortality. Reactive oxygen species (ROS), produced in part by the neutrophil NADPH oxidase 2 (Nox2), have been implicated in the pathogenesis of ALI. Previous studies in our laboratory demonstrated the development of pulmonary inflammation in Nox2-deficient (gp91

Indexed as

Acute Lung InjuryAnimalsCell MovementChemokinesInflammationLungMacrophages, AlveolarMiceNADPH Oxidase 2NeutrophilsReactive Oxygen SpeciesSystemic Inflammatory Response SyndromeChemokinesNADPH Oxidase 2Reactive Oxygen Speciesacute lung injuryalveolar macrophageARDSNADPH oxidase 2Nox2

Identifiers

PMID30288635
PMCPMC6775637
OpenAlexW2894648583

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.