Evidence map›Paper›PMID 30288602›Full record

Trial reportSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2019

Exercise improves functional capacity and lean body mass in patients with gastrointestinal cancer during chemotherapy: a single-blind RCT.

Katrin Stuecher, Claus Bolling, Lutz Vogt, Daniel Niederer, Katharina Schmidt, Axel Dignaß, Winfried Banzer

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 13 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 13 syntheses or guidelines pooled it.

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  2. Non-pharmacological interventions targeting mobility among people with advanced cancer: a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
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  7. Effect of exercise interventions in adults with cancer receiving palliative care: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Katrin StuecherDepartment of Sports Medicine, Goethe-University Frankfurt, Ginnheimer Landstr. 39, D-60487, Frankfurt/Main, Germany. katrin.stuecher@gmx.de.ORCID http://orcid.org/0000-0001-7265-3113
Claus BollingHead Department of Medicine I, Markus Hospital, Wilhelm-Epstein-Str. 4, D-60431, Frankfurt/Main, Germany.
Lutz VogtDepartment of Sports Medicine, Goethe-University Frankfurt, Ginnheimer Landstr. 39, D-60487, Frankfurt/Main, Germany.
Daniel NiedererDepartment of Sports Medicine, Goethe-University Frankfurt, Ginnheimer Landstr. 39, D-60487, Frankfurt/Main, Germany.
Katharina SchmidtDepartment of Sports Medicine, Goethe-University Frankfurt, Ginnheimer Landstr. 39, D-60487, Frankfurt/Main, Germany.
Axel DignaßHead Department of Medicine I, Markus Hospital, Wilhelm-Epstein-Str. 4, D-60431, Frankfurt/Main, Germany.
Winfried BanzerDepartment of Sports Medicine, Goethe-University Frankfurt, Ginnheimer Landstr. 39, D-60487, Frankfurt/Main, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeAlthough growing evidence underlines the benefits of physical activity as supportive intervention for cancer patients, sparse data are available for exercise in patients with advanced disease stages, in particular for gastrointestinal cancer (GIC) patients who experience specific disease-associated limitations. Thus, the aim of this study is to evaluate the effects of home-based moderate intensity exercise on functional capacity, activities of daily living (ADL) and body composition in patients with advanced GIC during first-line chemotherapy.

methodsParticipants (GIC, UICC III-IV; n = 44) were randomly assigned to home-based physical activity programme of 150 min moderate walking per week or a control group (CG). Functional status (SPPB: gait speed, balance, lower extremity muscle strength), postural sway, chemotherapy-induced peripheral neuropathy, nutritional state (Mini Nutritional Assessment, MNA) and lean body mass were assessed according to established recommendations. All tests were performed before chemotherapy (T0), after two chemotherapy cycles (T1) and after 12 weeks (T2).

resultsSPPB changes from T1 to T2 differed between groups with a comparably greater decrease in the CG (p < .05), but no changes or group differences over the whole study period (T0 to T2) were found. Exercise improved postural sway (T0 to T1; T0 toT2) and lean body mass (T1 to T2; T0 to T2) compared to the control group (p < .05). Gait speed, peripheral neuropathy and strength did not differ between groups (p > .05).

conclusionsOur results indicate that a home-based physical activity improves postural sway and body composition and might stabilize functional capacity in patients with advanced GIC during chemotherapy. Although the other outcomes did not differ between groups, aforementioned effects might contribute to a maintenance of independency in ADL and a better treatment tolerance and thus enhance patients' quality of life.

Indexed as

Body Mass IndexAgedExerciseFemaleGastrointestinal NeoplasmsHumansMaleMiddle AgedProspective StudiesQuality of LifeSingle-Blind MethodActivities of daily livingAdvanced cancerChemotherapyFunctional capacityGastrointestinal cancerPhysical activity

Identifiers

PMID30288602

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.