SynthesisInflammation research : official journal of the European Histamine Research Society ... [et al.]2019
C-reactive protein as a biomarker of severe H1N1 influenza.
Synthesis in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
60 citing papers in PubMed, 104 citations in OpenAlex.
- Gene expression patterns associated with influenza A and type I hypersensitivity in childhood appendicitis.World journal of pediatrics : WJP · 2026Article
- Heart Rate Fragmentation: A Novel Analytic Approach to Detect Allostatic Load Among Healthy Adults.Applied psychophysiology and biofeedback · 2026Article
- Impact of demographic, clinical, and viral factors on severe influenza in young children in Fuzhou.Frontiers in public health · 2026Article
- Development and internal validation of a nomogram for predicting referral or hospitalization risk in children with community-acquired influenza.Frontiers in pediatrics · 2026Article
- Analysis of epidemiological characteristics of influenza viruses in Fengdu district, Chongqing, China, from 2022 to 2024.Virology journal · 2025Review
- A simple, rapid, and cost-effective model for predicting critical influenza a infection in children: a multicentre, retrospective cohort study.BMC pediatrics · 2025Article
- Potential of biomarkers of ageing in predicting severity of influenza virus infection and vaccination efficacy.npj aging · 2025Review
- Multiomics analysis unveils key biomarkers during dynamic progress of IAV infection in mice.Frontiers in immunology · 2025Article
- Predicting Intensive Care Unit Admission in COVID-19-Infected Pregnant Women Using Machine Learning.Journal of clinical medicine · 2024Article
- Quantitative susceptibility mapping at 7 T in COVID-19: brainstem effects and outcome associations.Brain : a journal of neurology · 2024Article
- Biomarkers associated with vaccine-associated enhanced respiratory disease following influenza A virus infection in swine.Veterinary immunology and immunopathology · 2024Article
- C-Reactive Protein as a Predictor of Severe Respiratory Complications in Measles.Medicina (Kaunas, Lithuania) · 2024Article
- Demystifying COVID-19 mortality causes with interpretable data mining.Scientific reports · 2024Article
- A Design and Analytical Strategy for Monitoring Disease Positivity and Biomarker Levels in Accessible Closed Populations.American journal of epidemiology · 2024Article
- C-reactive protein: structure, function, regulation, and role in clinical diseases.Frontiers in immunology · 2024Review
- Clinical characteristics of severe influenza as a risk factor for febrile seizures in children: a retrospective analysis.Frontiers in pediatrics · 2024Article
- The Trend of C-Reactive Protein After Corticosteroid Therapy in COVID-19 Patients Admitted to IGIMS, Patna.Cureus · 2024Article
- Assessment of Some Risk Factors and Biological Predictors in the Post COVID-19 Syndrome in Asthmatic Patients.Journal of personalized medicine · 2023Article
- Comparative analysis of CRP as a biomarker of the inflammatory response intensity among common viral infections affecting the lungs: COVID-19 versus influenza A, influenza B and respiratory syncytial virus.Clinical and experimental medicine · 2023Article
- Association of C-reactive protein with mortality in Covid-19 patients: a secondary analysis of a cohort study.Scientific reports · 2023Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundC-reactive protein (CRP) is an acute-phase reactant downstream of the pro-inflammatory cytokines released during influenza infection. However, the role of this inflammatory marker in influenza severity and complications is yet to be elucidated.
objectivesWe aim to systematically review and evaluate the levels of CRP in severe and non-severe H1N1 influenza cases and assess its utility as a biomarker in predicting the severity of infection.
methodsWe conducted a comprehensive search in Ovid MEDLINE, Ovid MEDLINE (R) Epub ahead of Print, Embase and Embase Classic to identify human studies reporting measurements of CRP levels in patients infected with H1N1 influenza at various levels of disease severity.
resultsOur search identified ten studies eligible for inclusion in this systematic review. The results of the data analysis show that the average CRP levels upon diagnosis were significantly higher (P < 0.05) in patients who developed severe H1N1 influenza compared to their counterparts with a no severe disease. Furthermore, levels of CRP were associated with the degree of H1N1 severity. Subjects with H1N1-related pneumonia and patients who were hospitalized or died of the disease complications, respectively, had 1.4- and 2.5-fold significantly higher CRP levels (P < 0.05) than those with no severe disease outcome.
conclusionCRP levels have been consistently shown to be significantly higher in H1N1 influenza patients who develop a severe disease outcome. The resuts of the present study suggest that serum CRP can be employed-in combination with other biomarkers-to predict the complications of H1N1 influenza.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.