ArticleJournal of diabetes and metabolic disorders2018
Association of serum uric acid with nephropathy in Iranian type 2 diabetic patients.
Article in Journal of diabetes and metabolic disorders, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed.
- An overview of diabetes research achievements during a quarter of a century in Diabetes Research Center.Journal of diabetes and metabolic disorders · 2024Article
- Nephroprotective Effect ofACS omega · 2024Article
- Potential Plasma Metabolite Biomarkers of Diabetic Nephropathy: Untargeted Metabolomics Study.Journal of personalized medicine · 2022Article
- Serum and urine metabolomics reveal potential biomarkers of T2DM patients with nephropathy.Annals of translational medicine · 2020Article
- Association between serum 25-hydroxyvitamin D and diabetic kidney disease in Chinese patients with type 2 diabetes.PloS one · 2019Article
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3 authors.
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Abstract
backgroundDiabetic nephropathy (DN) is the major cause of end-stage renal disease. Recent studies suggest that it is probable that uric acid is involved in the pathogenesis of diabetic nephropathy. This study aim was to investigate the association between serum uric acid and kidney function in Iranian patients with type 2 diabetes mellitus.
methodsIn this case-control study, a total of 201 diabetic patients with or without impaired kidney function (glomerular filtration rate/GFR < 60 and GFR ≥ 60) were selected. In both groups, serum fasting glucose (FBS), HbA1c, urea, creatinine, uric acid and lipid profile, urine albumin and GFR were measured and results were compared between the two groups. The results also categorized into three groups based on uric acid tertiles.
resultsSerum levels of uric acid, urea and creatinine as well as urine albumin/creatinine ratio (ACR) were significantly different between the two groups. GFR, creatinine and also urea were significantly different between uric acid tertiles (
conclusionsSerum uric acid is associated with decreased GFR as well as albuminuria and can be used as an indicator of DN.
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