Evidence map›Paper›PMID 30288342›Full record

ArticleOncoimmunology

A point mutation in the

Francisca F Almeida, Sara Tognarelli, Antoine Marçais, Andrew J Kueh, Miriam E Friede, Yang Liao, Simon N Willis, Kylie Luong, Fabrice Faure, Francois E Mercier and 22 more

Open access · goldAbstract read
In one paragraph

Article in Oncoimmunology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. An engineered NKp46 antibody for construction of multi-specific NK cell engagers.Protein engineering, design & selection : PEDS · 2024
    Article
  4. ILC3: a case of conflicted identity.Frontiers in immunology · 2023
    Review
  5. Innate lymphoid cells type 3 in cancer.Frontiers in immunology · 2022
    Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

32 authors at 8 institutions in 5 countries.

Francisca F AlmeidaDivision of Molecular Immunology, Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.ORCID 0000-0001-6632-7610
Sara TognarelliDivision of Stem Cell Transplantation and Immunology, Department for Children and Adolescents Medicine, Johann Wolfgang Goethe University Hospital, Frankfurt am Main, Germany.
Antoine MarçaisCIRI, Centre International de Recherche en Infectiologie - International Center for Infectiology Research, Inserm, U1111, CNRS, UMR5308, Ecole Normale Supérieure de Lyon, Université Lyon 1, Lyon, France.
Andrew J KuehDivision of Molecular Immunology, Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
Miriam E FriedeInstitute for Molecular Medicine, Johann Wolfgang Goethe University, Frankfurt am Main, Germany.
Yang LiaoDivision of Molecular Immunology, Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
Simon N WillisDivision of Molecular Immunology, Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
Kylie LuongDivision of Molecular Immunology, Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
Fabrice FaureCIRI, Centre International de Recherche en Infectiologie - International Center for Infectiology Research, Inserm, U1111, CNRS, UMR5308, Ecole Normale Supérieure de Lyon, Université Lyon 1, Lyon, France.
Francois E MercierDepartment of Medicine, McGill University, Montreal, Quebec, Canada.
Justine GallusoCNRS, INSERM, CIML, Centre d'Immunologie de Marseille-Luminy, Aix Marseille University, Marseille, France.
Matthew FirthDivision of Molecular Immunology, Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
Emilie Narni-MancinelliCNRS, INSERM, CIML, Centre d'Immunologie de Marseille-Luminy, Aix Marseille University, Marseille, France.
Bushra RaisDivision of Stem Cell Transplantation and Immunology, Department for Children and Adolescents Medicine, Johann Wolfgang Goethe University Hospital, Frankfurt am Main, Germany.
David T ScaddenHarvard Stem Cell Institute, Cambridge, MA, USA.
Francesco SpallottaDivision of Cardiovascular Epigenetics, Department of Cardiology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany.
Sandra WeilGeorg Speyer Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt am Main, Germany.
Ariane GiannattasioGeorg Speyer Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt am Main, Germany.
Franziska KalenseeDivision of Stem Cell Transplantation and Immunology, Department for Children and Adolescents Medicine, Johann Wolfgang Goethe University Hospital, Frankfurt am Main, Germany.
Tobias ZöllerInstitute for Molecular Medicine, Johann Wolfgang Goethe University, Frankfurt am Main, Germany.
Nicholas D HuntingtonDivision of Molecular Immunology, Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
Ulrike SchleicherMikrobiologisches Institut-Klinische Mikrobiologie, Immunologie und Hygiene, Friedrich-Alexander-Universität Erlangen-Nürnberg und Universitätsklinikum Erlangen, Erlangen, Germany.
Andreas G ChiocchettiMolecular Genetics Laboratory, Department for Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Johann Wolfgang Goethe University, Frankfurt am Main, Germany.
Sophie UgoliniCNRS, INSERM, CIML, Centre d'Immunologie de Marseille-Luminy, Aix Marseille University, Marseille, France.ORCID 0000-0003-4041-0103
Marco J HeroldDivision of Molecular Immunology, Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
Wei ShiDivision of Molecular Immunology, Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
Joachim KochGeorg Speyer Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt am Main, Germany.
Alexander SteinleInstitute for Molecular Medicine, Johann Wolfgang Goethe University, Frankfurt am Main, Germany.ORCID 0000-0001-5081-8503
Eric VivierCNRS, INSERM, CIML, Centre d'Immunologie de Marseille-Luminy, Aix Marseille University, Marseille, France.ORCID 0000-0001-7022-8287
Thierry WalzerCIRI, Centre International de Recherche en Infectiologie - International Center for Infectiology Research, Inserm, U1111, CNRS, UMR5308, Ecole Normale Supérieure de Lyon, Université Lyon 1, Lyon, France.
Gabrielle T BelzDivision of Molecular Immunology, Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.ORCID 0000-0002-9660-9587
Evelyn UllrichLOEWE Center for Cell and Gene Therapy, Johann Wolfgang Goethe University, Frankfurt am Main, Germany.ORCID 0000-0001-8530-1192
The University of Melbourne · AUGoethe University Frankfurt · DECentre National de la Recherche Scientifique · FRJohannes Gutenberg University Mainz · DEUniversité Claude Bernard Lyon 1 · FRFriedrich-Alexander-Universität Erlangen-Nürnberg · DEHarvard Stem Cell Institute · USMcGill University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

NKp46 (CD335) is a surface receptor shared by both human and mouse natural killer (NK) cells and innate lymphoid cells (ILCs) that transduces activating signals necessary to eliminate virus-infected cells and tumors. Here, we describe a spontaneous point mutation of cysteine to arginine (C14R) in the signal peptide of the NKp46 protein in congenic Ly5.1 mice and the newly generated NCR

Indexed as

activation receptorscongenic miceinnate lymphoid cellsintracellular trafficking

Identifiers

PMID30288342
PMCPMC6169588
OpenAlexW2886634548

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.