ArticleVirus evolution2018
Beneficial coinfection can promote within-host viral diversity.
Article in Virus evolution, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 52 citations in OpenAlex.
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- Rapid glycoprotein evolution enables variant interactions in herpes simplex virus type 1.Virus evolution · 2025Article
- Diverse phage communities are maintained stably on a clonal bacterial host.Science (New York, N.Y.) · 2024Article
- Spillover: Mechanisms, Genetic Barriers, and the Role of Reservoirs in Emerging Pathogens.Microorganisms · 2024Review
- Mammalian orthoreovirus can exit cells in extracellular vesicles.PLoS pathogens · 2024Article
- Open questions in the social lives of viruses.Journal of evolutionary biology · 2023Review
- Novel Recombinant Rabbit Hemorrhagic Disease Virus 2 (RHDV2) is Circulating in China within 12 Months after Original RHDV2 Arrival.Transboundary and emerging diseases · 2023Article
- Vector-virus interaction affects viral loads and co-occurrence.BMC biology · 2022Article
- Superinfection exclusion: A viral strategy with short-term benefits and long-term drawbacks.PLoS computational biology · 2022Article
- Simultaneous enterovirus EV-D68 and CVA6 infections causing acute respiratory distress syndrome and hand, foot and mouth disease.Virology journal · 2021Article
- The Epidemiology of Plant Virus Disease: Towards a New Synthesis.Plants (Basel, Switzerland) · 2020Review
- Recombination at the emergence of the pathogenic rabbit haemorrhagic disease virus Lagovirus europaeus/GI.2.Scientific reports · 2020Article
- Competition between social cheater viruses is driven by mechanistically different cheating strategies.Science advances · 2020Article
- Article
- Modeling multipartite virus evolution: the genome formula facilitates rapid adaptation to heterogeneous environmentsVirus evolution · 2020Article
- A proofreading-impaired herpesvirus generates populations with quasispecies-like structure.Nature microbiology · 2019Article
- Membrane-Associated Enteroviruses Undergo Intercellular Transmission as Pools of Sibling Viral Genomes.Cell reports · 2019Article
- Uncovering Virus-Virus Interactions by Unifying Approaches and Harnessing High-Throughput Tools.mSystems · 2019Article
- The evolution of collective infectious units in viruses.Virus research · 2019Article
- Multiple infection of cells changes the dynamics of basic viral evolutionary processes.Evolution letters · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
In many viral infections, a large number of different genetic variants can coexist within a host, leading to more virulent infections that are better able to evolve antiviral resistance and adapt to new hosts. But how is this diversity maintained? Why do faster-growing variants not outcompete slower-growing variants, and erode this diversity? One hypothesis is if there are mutually beneficial interactions between variants, with host cells infected by multiple different viral genomes producing more, or more effective, virions. We modelled this hypothesis with both mathematical models and simulations, and found that moderate levels of beneficial coinfection can maintain high levels of coexistence, even when coinfection is relatively rare, and when there are significant fitness differences between competing variants. Rare variants are more likely to be coinfecting with a different variant, and hence beneficial coinfection increases the relative fitness of rare variants through negative frequency dependence, and maintains diversity. We further find that coexisting variants sometimes reach unequal frequencies, depending on the extent to which different variants benefit from coinfection, and the ratio of variants which leads to the most productive infected cells. These factors could help drive the evolution of defective interfering particles, and help to explain why the different segments of multipartite viruses persist at different equilibrium frequencies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.