Evidence map›Paper›PMID 30288276›Full record

ArticleUnited European gastroenterology journal2018

Physical activity, sedentary behaviour and risk of oesophago-gastric cancer: A prospective cohort study within UK Biobank.

Andrew T Kunzmann, Kristian P Mallon, Ruth F Hunter, Chris R Cardwell, Úna C McMenamin, Andrew D Spence, Helen G Coleman

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in United European gastroenterology journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 4 pooled it
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 4 syntheses or guidelines pooled it, 28 citations in OpenAlex.

  1. Pooled it
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  8. Practical Considerations in Diagnosing and Managing Early-Onset GI Cancers.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Andrew T KunzmannCancer Epidemiology Group, Centre for Public Health, Queen's University Belfast, Belfast, UK.ORCID https://orcid.org/0000-0001-9363-566X
Kristian P MallonCancer Epidemiology Group, Centre for Public Health, Queen's University Belfast, Belfast, UK.
Ruth F HunterUKCRC Centre of Excellence for Public Health (NI), Queen's University Belfast, Belfast, UK.
Chris R CardwellCancer Epidemiology Group, Centre for Public Health, Queen's University Belfast, Belfast, UK.
Úna C McMenaminCancer Epidemiology Group, Centre for Public Health, Queen's University Belfast, Belfast, UK.
Andrew D SpenceCancer Epidemiology Group, Centre for Public Health, Queen's University Belfast, Belfast, UK.ORCID https://orcid.org/0000-0001-5026-4758
Helen G ColemanCancer Epidemiology Group, Centre for Public Health, Queen's University Belfast, Belfast, UK.
Queen's University Belfast · GB

Funding

Cancer Research UK 20100Medical Research Council MC_PC_17228Medical Research Council MC_QA137853
6 · The paper itself

Abstract

backgroundFew observational studies have assessed the role of physical activity in oesophago-gastric cancer risk.

objectiveThis prospective cohort study aimed to assess the association between physical activity and risk of oesophageal or gastric cancer.

methodsA cohort of 359,033 adults aged 40-69 years were identified from the UK Biobank, which recruited participants between 2006 and 2010. Adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for the associations between self-reported levels of physical activity and screen-based sedentary behaviour and risk of oesophageal and gastric cancer were calculated using Cox proportional hazards models.

resultsDuring eight years of follow-up (mean = 5.5), 294 oesophageal cancer and 217 gastric cancer cases were identified. Physical activity and screen-based sedentary behaviour levels were not associated with overall oesophago-gastric cancer risk. However, when compared with low levels, high physical activity levels were associated with a significantly reduced risk of gastric non-cardia cancer (HR 0.58, 95% CI 0.37-0.95). Moderate physical activity levels were associated with a 38% reduced risk of oesophageal adenocarcinoma (HR 0.62, 95% CI 0.43-0.89), although no dose-response association was apparent.

conclusionModerate, rather than high, physical activity levels were associated with the strongest reductions in oesophageal adenocarcinoma risk in this large UK prospective cohort.

Indexed as

adenocarcinomagastric cancerOesophageal cancerphysical activitysedentary behaviour

Identifiers

PMID30288276
PMCPMC6169059
OpenAlexW2805907123

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.