ArticleClinical kidney journal2018
Haemodynamic or metabolic stimulation tests to reveal the renal functional response: requiem or revival?
Article in Clinical kidney journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 30 citations in OpenAlex.
- Renal vascular control during normothermia and passive heat stress does not differ between healthy younger men and women.American journal of physiology. Renal physiology · 2024Trial
- Glomerular filtration rate reserve is reduced during mild passive heat stress in healthy young adults.American journal of physiology. Regulatory, integrative and comparative physiology · 2022Trial
- Cystatin-C outperforms creatinine for estimating renal function in adolescents with anorexia nervosa: cross-sectional method-comparison study.Journal of eating disorders · 2026Article
- Assessment, molecular mechanisms and therapeutic targets for renal functional reserve.Renal failure · 2025Review
- Preventing acute kidney injury and its longer-term impact in the critically ill.Intensive care medicine · 2025Review
- Renal hypertrophy and hyperfiltration is enhanced in early acquired compared with a congenital solitary function kidney model in sheep.Clinical science (London, England : 1979) · 2025Article
- Evaluation of renal functional reserve with oral protein load or new ultrasound test.Journal of nephrology · 2025Article
- Glomerular hyperfiltration as a therapeutic target for CKD.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2024Review
- Testing the functional reserve of the kidney before hematopoietic stem cell transplantation: doubt remains.Clinical kidney journal · 2023Article
- Atherosclerosis Specific Features in Chronic Kidney Disease (CKD).Biomedicines · 2022Review
- Acute kidney injury and aging.Pediatric nephrology (Berlin, Germany) · 2021Review
- Kidney physiology and pathophysiology during heat stress and the modification by exercise, dehydration, heat acclimation and aging.Temperature (Austin, Tex.) · 2021Review
- Measurement of renal functional response using iohexol clearance-a study of different outpatient procedures.Clinical kidney journal · 2021Article
- A call to action to evaluate renal functional reserve in patients with COVID-19.American journal of physiology. Renal physiology · 2020Article
- A Systematic Review of Renal Functional Reserve in Adult Living Kidney Donors.Kidney international reports · 2020Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Renal stimulation tests document the dynamic response of the glomerular filtration rate (GFR) after a single or a combination of stimuli, such as an intravenous infusion of dopamine or amino acids or an oral protein meal. The increment of the GFR above the unstimulated state has formerly been called the renal functional reserve (RFR). Although the concept of a renal reserve capacity has not withstood scientific scrutiny, the literature documenting renal stimulation merits renewed interest. An absent or a blunted response of the GFR after a stimulus indicates lost or diseased nephrons. This information is valuable in preventing, diagnosing and prognosticating acute kidney injury and pregnancy-related renal events as well as chronic kidney disease. However, before renal function testing is universally practiced, some shortcomings must be addressed. First, a common nomenclature should be decided upon. The expression of RFR should be replaced by renal functional response. Second, a simple protocol must be developed and propagated. Third, we suggest designing prospective studies linking a defective stimulatory response to emergence of renal injury biomarkers, to histological or morphological renal abnormalities and to adverse renal outcomes in different renal syndromes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.