ArticleBioPsychoSocial medicine2018
Association between chronological depressive changes and physical symptoms in postoperative pancreatic cancer patients.
Article in BioPsychoSocial medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.
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Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 16 citations in OpenAlex.
- Impact of Depression on Mortality in Patients with Pancreatic Cancer: A Systematic Review.Current oncology (Toronto, Ont.) · 2025Pooled it
- Pooled it
- Network structure and temporal stability of symptoms during perioperative period among gastrointestinal cancer patients.Journal of cancer survivorship : research and practice · 2026Article
- Machine Learning-Based Classification of Depression Using Inflammatory Biomarkers in Pancreatic Cancer Patients.The Kaohsiung journal of medical sciences · 2026Article
- Review
- Preoperative anxiety state is an independent risk factor for delayed gastric emptying after pylorus-preserving pancreaticoduodenectomy: a single-center retrospective case-control study.Annals of medicine · 2025Observational
- Symptom cluster in patients with resected pancreatic cancer during adjuvant chemotherapy: A cross-sectional study.Asia-Pacific journal of oncology nursing · 2025Article
- A Quality Assessment of the Information Accessible to Patients on the Internet About the Whipple Procedure.World journal of surgery · 2021Article
- Patient-Reported Outcomes in Surgical Oncology: An Overview of Instruments and Scores.Annals of surgical oncology · 2020Article
- Update on current pancreatic treatments: from molecular pathways to treatment.Journal of Cancer · 2019Review
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPancreatic cancer (PC) has poorer prognosis and higher surgical invasiveness than many other cancers, with associated psychiatric symptoms including depression and anxiety. Perioperative depression has not been investigated in PC patients regarding surgical stress and relevant interventions.
methodsWe evaluated chronological depressive changes and subjective physical symptoms in surgically treated PC patients preoperatively and at 3 and 6 months postoperatively.Enrolled patients undergoing pancreatic tumor surgery completed questionnaires based on the Self-Rating Depression Scale (SDS) and Functional Assessment of Cancer Therapy for Patients with Hepatobiliary Cancer (FACT-Hep) preoperatively, and at 3 and 6 months postoperatively. Responses were analyzed with JMP® Pro using one-way and two-way ANOVA, Spearman's rank correlation coefficient, and multiple regression analysis.
resultsMalignancy was diagnosed in 73 of 101 patients postoperatively; SDS score was significantly higher in these patients than in those with benign tumors at all timepoints: malignant/benign, 41.8/37.9 preoperatively (
conclusionsPC patients experience persistently high levels of depression preoperatively through 6 months postoperatively, with associated subjective symptoms including pain and gastrointestinal symptoms.
trial registrationUMIN Clinical Trials Registry 000009592, Registered 20 December 2012.
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