ArticleClinical epidemiology2018
Determinants of incident asthma-COPD overlap: a prospective study of 55,110 middle-aged adults.
Article in Clinical epidemiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 10 citations in OpenAlex.
- Management of comorbidities in difficult and severe asthma.Breathe (Sheffield, England) · 2023Review
- ACO (Asthma-COPD Overlap) Is Independent from COPD: The Case in Favour.Diagnostics (Basel, Switzerland) · 2021Review
- European Respiratory Society International Congress 2017: highlights from the Clinical Assembly.ERJ open research · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimKnowledge of the impact of social determinants driving asthma- chronic obstructive pulmonary disease overlap (ACO) is lacking. Our objective was to identify determinants of incident ACO.
methodsA total of 55,053 adults (50-64 years) enrolled in the Danish Diet, Cancer, and Health cohort (1993-97) was followed in the National Patient Registry for admissions for asthma (DJ45-46) and chronic obstructive pulmonary disease (COPD; DJ40-44) and vital status. Incident ACO was defined as at least one hospital admission for both asthma and COPD (different time points, one after baseline). Detailed case history was obtained at baseline. Cox proportional hazards model was used to examine associations between possible determinants and incident ACO, in terms of hazard ratio (HR) and 95% confidence interval (CI).
resultsDuring follow-up, 561 incident cases of ACO were identified. Age (HR 4.4, 95% CI 3.3-5.9, age group 60-65 years), current smoking (HR 3.6, 95% CI 2.8-4.6), unemployment (HR 1.5, 95% CI 1.2-1.8), and being divorced (HR 1.5, 95% CI 1.2-1.9) determined a higher risk of incident ACO, whereas the opposite was found for leisure-time physical activity (HR 0.7, 95% CI 0.6-0.8) and high educational level (HR 0.7, 95% CI 0.5-0.9). In contrast to ACO, preexisting myocardial infarction (MI; HR 1.5, 95% CI 1.2-1.8) and stroke (HR 1.5, 95% CI 1.2-1.9) were associated with a higher risk of COPD.
conclusionIncident ACO is to a large extent determined by factors related to lifestyle and socioeconomic status.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.