Evidence map›Paper›PMID 30288039›Full record

ArticleInternational journal of nanomedicine2018

Effects of PEG surface density and chain length on the pharmacokinetics and biodistribution of methotrexate-loaded chitosan nanoparticles.

Zaina Ait Bachir, YuKun Huang, MuYe He, Lei Huang, XinYu Hou, RongJun Chen, Feng Gao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of nanomedicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Article
  8. Application of mPEG-CS-cRGD/Drug delivery · 2023
    Article
  9. Article
  10. Impact of nanocarrier aggregation on EPR-mediated tumor targeting.Frontiers in bioengineering and biotechnology · 2023
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 2 countries.

Zaina Ait BachirShanghai Key Laboratory of Functional Materials Chemistry, East China University of Science and Technology, Shanghai, People's Republic of China, fgao@ecust.edu.cn.
YuKun HuangShanghai Key Laboratory of Functional Materials Chemistry, East China University of Science and Technology, Shanghai, People's Republic of China, fgao@ecust.edu.cn.
MuYe HeShanghai Key Laboratory of Functional Materials Chemistry, East China University of Science and Technology, Shanghai, People's Republic of China, fgao@ecust.edu.cn.
Lei HuangShanghai Key Laboratory of Functional Materials Chemistry, East China University of Science and Technology, Shanghai, People's Republic of China, fgao@ecust.edu.cn.
XinYu HouShanghai Key Laboratory of Functional Materials Chemistry, East China University of Science and Technology, Shanghai, People's Republic of China, fgao@ecust.edu.cn.
RongJun ChenDepartment of Chemical Engineering, Imperial College London, South Kensington Campus, London, UK, rongjun.chen@imperial.ac.uk.
Feng GaoShanghai Key Laboratory of Functional Materials Chemistry, East China University of Science and Technology, Shanghai, People's Republic of China, fgao@ecust.edu.cn.
East China University of Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOne of the most important aspects of drug delivery is extended nanoparticle (NP) residence time in vivo. Herein, we report a series of methotrexate (MTX)-loaded chito-san (CS) NPs coated with differently sized methoxy polyethylene glycol (mPEG) at different mPEG surface densities. MATERIALS AND

methodsMTX was incorporated into NPs (112.8-171.2 nm in diameter) prepared from the resulting mPEG-g-CS. The NPs had a zeta potential of +7.4-35.0 mV and MTX loading efficiency of 17.1%-18.4%. MTX/mPEG-g-CS NPs showed an initial burst release of MTX followed by a sustained-release profile in PBS at pH 7.4.

resultsThe in vitro cellular uptake study showed that MTX accumulation in J774A.1 macrophage cells decreased with increasing the mPEG surface density or the mPEG molecular weight. The pharmacokinetic study on Sprague Dawley rats revealed an increase in AUC0-72 h (area under the plasma drug concentration-time curve over a period of 72 hours) with increasing the mPEG surface density or the mPEG molecular weight and a linear correlation between the mPEG surface density and AUC

conclusionThe biodistribution study on Institute of Cancer Research (ICR) mice revealed that MTX/mPEG-g-CS NPs significantly enhanced blood circulation time in the body and decreased accumulation in liver, spleen, and lung. These results suggest the potential of the mPEG-g-CS NPs as a promising candidate for drug delivery.

Indexed as

AnimalsArea Under CurveCell LineChitosanDrug CarriersDrug Delivery SystemsDrug LiberationEndocytosisMethotrexateMice, Inbred ICRNanoparticlesParticle SizePolyethylene GlycolsRats, Sprague-DawleySurface PropertiesTissue DistributionChitosanDrug CarriersMethotrexatemonomethoxypolyethylene glycolPolyethylene Glycolschitosandrug delivery systemsmethotrexatenanoparticlesPEGylation

Identifiers

PMID30288039
PMCPMC6161721
OpenAlexW2889894210

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.