ReviewBritish journal of cancer2018
The colorectal cancer epidemic: challenges and opportunities for primary, secondary and tertiary prevention.
Review in British journal of cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 160 papers, 10 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
160 citing papers in PubMed, 10 syntheses or guidelines pooled it, 301 citations in OpenAlex.
- Apathy and Physical Activity: A Systematic Review and Meta-Analysis.Physiotherapy Canada. Physiotherapie Canada · 2026Pooled it
- One- versus two-sample fecal immunochemical testing for colorectal cancer screening: a systematic review and meta-analysis of participation, diagnostic performance, and cost-effectiveness.BMC gastroenterology · 2026Pooled it
- Pharmacist-Led Interventions for Colorectal Cancer Prevention: A Systematic Review.Current oncology (Toronto, Ont.) · 2026Pooled it
- Global research trends inFrontiers in cellular and infection microbiology · 2026Pooled it
- Relationship Between Fear of Movement and Physical Activity in Patients With Cardiac, Rheumatologic, Neurologic, Pulmonary, or Pain Conditions: A Systematic Review and Meta-Analysis.Physical therapy · 2025Pooled it
- Frailty worsens long-term survival in patients with colorectal cancer: a systematic review and meta-analysis.Frontiers in oncology · 2024Pooled it
- National and subnational incidence, mortality and associated factors of colorectal cancer in China: A systematic analysis and modelling study.Journal of global health · 2023Pooled it
- The Efficacy and Safety of Celecoxib in Addition to Standard Cancer Therapy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Current oncology (Toronto, Ont.) · 2022Pooled it
- The impact of hepatic steatosis on outcomes of colorectal cancer patients with liver metastases: A systematic review and meta-analysis.Frontiers in medicine · 2022Pooled it
- Prognostic value of the geriatric nutritional index in colorectal cancer patients undergoing surgical intervention: A systematic review and meta-analysis.Frontiers in oncology · 2022Pooled it
- Modulating a prebiotic food source influences inflammation and immune-regulating gut microbes and metabolites: insights from the BE GONE trial.EBioMedicine · 2023Trial
- Evaluating incidence and mortality trends of early-onset colorectal cancer and adenoma in Belgium.ESMO gastrointestinal oncology · 2026Article
- Temporal trends of clinicopathological features, therapeutic modalities, and survival outcomes in pseudo-age-related colorectal cancer.Scientific reports · 2026Article
- Unraveling colorectal cancer incidence dynamics in Hong Kong 1983-2032 through age-period-cohort Bayesian projection and decomposition analysis.Archives of public health = Archives belges de sante publique · 2026Article
- Trends in colorectal cancer burden attributable to lifestyle in China (1990-2021): based on the global burden of disease study, revealing declining impact of dietary factors and rising influence of tobacco, alcohol, and obesity.Journal of health, population, and nutrition · 2026Article
- Understanding the Impact of Psychosocial Barriers on Colorectal Cancer Knowledge in Emerging Adult Black Men.Journal of cancer education : the official journal of the American Association for Cancer Education · 2026Article
- Peroxiredoxin 1, pyroptosis, and the emerging frontier in colorectal cancer therapy.World journal of gastroenterology · 2026Article
- Prognostic value of a modified lymph node ratio for combined colorectal cancer tumour deposits: a population-based study.Frontiers in oncology · 2026Article
- Novel benzofuran/pterostilbene hybrids trigger programmed cell death and impair migration in CRC cells.PloS one · 2026Article
- An interpretable machine learning model for predicting distant organ metastasis after radical resection of colorectal cancer.Frontiers in oncology · 2026Article
100 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Colorectal cancer (CRC) is both one of the most common and one of the most preventable cancers globally, with powerful but strongly missed potential for primary, secondary and tertiary prevention. CRC incidence has traditionally been the highest in affluent Western countries, but it is now increasing rapidly with economic development in many other parts of the world. CRC shares several main risk factors, such as smoking, excessive alcohol consumption, physical inactivity and being overweight, with other common diseases; therefore, primary prevention efforts to reduce these risk factors are expected to have multiple beneficial effects that extend beyond CRC prevention, and should have high public health impact. A sizeable reduction in the incidence and mortality of CRC can also be achieved by offering effective screening tests, such as faecal immunochemical tests, flexible sigmoidoscopy and colonoscopy, in organised screening programmes which have been implemented in an increasing number of countries. Countries with early and high uptake rates of effective screening have exhibited major declines in CRC incidence and mortality, in contrast to most other countries. Finally, increasing evidence shows that the prognosis and quality of life of CRC patients can be substantially improved by tertiary prevention measures, such as the administration of low-dose aspirin and the promotion of physical activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.