ReviewNature reviews. Neurology2018
A cross-species approach to disorders affecting brain and behaviour.
Review in Nature reviews. Neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed.
- Advances in biomarker discovery for canine cognitive dysfunction: a comprehensive structured narrative review and future perspectives.Veterinary research communications · 2026Review
- Canine Idiopathic Epilepsy as a Natural Animal Model for Human Epilepsy: A Scoping Review Highlighting Metabolic Perspectives Beyond the Brain.Nutrients · 2026Article
- Incorporating farm animal models for the study of neuropsychiatric diseases: Expansion of the possibilities.Cognitive, affective & behavioral neuroscience · 2026Review
- Canine EEG helps human: cross-species and cross-modality epileptic seizure detection via multi-space alignment.National science review · 2025Article
- Distinctive seizure signature in the first video case-control study of a naturally-occurring feline autoimmune encephalitis model.Brain, behavior, and immunity · 2025Article
- Tools for the Approach of Fear, Anxiety, and Stress in the Domestic Feline: An Update.Veterinary medicine international · 2025Review
- Exploring the singularity of human neurons: keep calm and carry on.Frontiers in synaptic neuroscience · 2025Review
- Morphological and Metabolic Features of Brain Aging in Rodents, Ruminants, Carnivores, and Non-Human Primates.Animals : an open access journal from MDPI · 2024Review
- Case report: Antibodies to myelin basic protein in a podenco-crossbreed dog with seizures.Frontiers in veterinary science · 2024Article
- Going beyond established model systems of Alzheimer's disease: companion animals provide novel insights into the neurobiology of aging.Communications biology · 2023Review
- On the identification of potential novel therapeutic targets for spinocerebellar ataxia type 1 (SCA1) neurodegenerative disease using EvoPPI3.Journal of integrative bioinformatics · 2023Article
- A framework for testing pathways from prenatal stress-responsive hormones to cardiovascular disease risk.Frontiers in endocrinology · 2023Review
- The value of broad taxonomic comparisons in evolutionary medicine: Disease is not a trait but aMedComm · 2022Article
- Parallel roles of neuroinflammation in feline and human epilepsies.Veterinary journal (London, England : 1997) · 2022Review
- Case Report: Anti-GABAFrontiers in veterinary science · 2022Article
- Autoantibodies in neurological disease.Nature reviews. Immunology · 2021Review
- Meningeal B Cell Clusters Correlate with Submeningeal Pathology in a Natural Model of Multiple Sclerosis.Journal of immunology (Baltimore, Md. : 1950) · 2021Article
- Feline cognitive dysfunction as a model for Alzheimer's disease in the research of CBD as a potential treatment-a narrative review.Journal of cannabis research · 2020Review
- Alzheimer's disease: many failed trials, so where do we go from here?Journal of investigative medicine : the official publication of the American Federation for Clinical Research · 2020Article
- APOE-amyloid interaction: Therapeutic targets.Neurobiology of disease · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Structural and functional elements of biological systems are highly conserved across vertebrates. Many neurological and psychiatric conditions affect both humans and animals. A cross-species approach to the study of brain and behaviour can advance our understanding of human disorders via the identification of unrecognized natural models of spontaneous disorders, thus revealing novel factors that increase vulnerability or resilience, and via the assessment of potential therapies. Moreover, diagnostic and therapeutic advances in human neurology and psychiatry can often be adapted for veterinary patients. However, clinical and research collaborations between physicians and veterinarians remain limited, leaving this wealth of comparative information largely untapped. Here, we review pain, cognitive decline syndromes, epilepsy, anxiety and compulsions, autoimmune and infectious encephalitides and mismatch disorders across a range of animal species, looking for novel insights with translational potential. This comparative perspective can help generate novel hypotheses, expand and improve clinical trials and identify natural animal models of disease resistance and vulnerability.
Indexed as
Identifiers
30287906What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.