Evidence map›Paper›PMID 30287828›Full record

ArticleTranslational psychiatry2018

Altered cerebral benzodiazepine receptor binding in post-traumatic stress disorder.

Inbal Reuveni, Allison C Nugent, Jessica Gill, Meena Vythilingam, Paul J Carlson, Alicja Lerner, Alexander Neumeister, Dennis S Charney, Wayne C Drevets, Omer Bonne

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Review
  3. The Person's Care Requires a Sex and Gender Approach.Journal of clinical medicine · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 3 countries.

Inbal ReuveniDepartment of Psychiatry, Hadassah Hebrew University Medical Center, Jerusalem, Israel.
Allison C NugentExperimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
Jessica GillCenter for Neuroscience and Regenerative Medicine (CNRM), National Institutes of Health, Bethesda, MD, USA.
Meena VythilingamDeployment Health Clinical Center, Defense Centers of Excellence for Psychological Health and Traumatic Brain Injury, Silver Spring, MD, USA.
Paul J CarlsonDepartment of Psychiatry, University of Utah School of Medicine, Salt Lake City, UT, USA.
Alicja LernerControlled Substance Staff, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA.
Alexander NeumeisterInstitute of Mental Health Research (IMHR), University of Ottawa, Ottawa, ON, Canada.
Dennis S CharneyMood and Anxiety Disorders Program, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Wayne C DrevetsJanssen Research and Development, LLC of Johnson & Johnson Inc., Titusville, NJ, USA.
Omer BonneDepartment of Psychiatry, Hadassah Hebrew University Medical Center, Jerusalem, Israel. bonne@hadassah.org.il.
Hadassah Medical Center · ILNational Institutes of Health · USCenter for Drug Evaluation and Research · USIcahn School of Medicine at Mount Sinai · USJanssen (United States) · USUniversity of Ottawa · CAUniversity of Utah · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Agonists of the γ-aminobutyric acid (GABA) type A benzodiazepine (BZD) receptor exert anxiolytic effects in anxiety disorders, raising the possibility that altered GABA-ergic function may play a role in the pathophysiology of anxiety disorders, such as post-traumatic stress disorder (PTSD). However, few neuroimaging studies have assessed the function or binding potential of the central GABA

Indexed as

AdultCarbon RadioisotopesCerebral CortexFemaleFlumazenilGyrus CinguliHumansMaleParietal LobePositron-Emission TomographyReceptors, GABA-AStress Disorders, Post-TraumaticCarbon RadioisotopesFlumazenilReceptors, GABA-A

Identifiers

PMID30287828
PMCPMC6172250
OpenAlexW2895464022

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.