ArticleNature communications2018
Selective prebiotic conversion of pyrimidine and purine anhydronucleosides into Watson-Crick base-pairing arabino-furanosyl nucleosides in water.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 42 citations in OpenAlex.
- On-Demand Photoprotection by UV-Transparent Small Molecules via Aggregation-Induced Absorption: The Origin and Modern Application.ACS central science · 2026Article
- Impact of 2'-deoxyribo-purine substrates on nonenzymatic RNA template-directed primer extension.Nucleic acids research · 2025Article
- Constraints on the emergence of RNA through non-templated primer extension with mixtures of potentially prebiotic nucleotides.Nucleic acids research · 2024Article
- Photoinduced charge separation and DNA self-repair depend on sequence directionality and stacking pattern.Chemical science · 2024Article
- Photochemistry of 2-thiooxazole: a plausible prebiotic precursor to RNA nucleotides.Physical chemistry chemical physics : PCCP · 2022Article
- Computational Analysis of a Prebiotic Amino Acid Synthesis with Reference to Extant Codon-Amino Acid Relationships.Life (Basel, Switzerland) · 2021Article
- Prebiotic Photochemical Coproduction of Purine Ribo- and Deoxyribonucleosides.Journal of the American Chemical Society · 2021Article
- Timescales for Prebiotic Photochemistry Under Realistic Surface Ultraviolet Conditions.Astrobiology · 2021Article
- Ribose Alters the Photochemical Properties of the Nucleobase in Thionated Nucleosides.The journal of physical chemistry letters · 2021Article
- 2,6-diaminopurine promotes repair of DNA lesions under prebiotic conditions.Nature communications · 2021Article
- Illuminating Life's Origins: UV Photochemistry in Abiotic Synthesis of Biomolecules.Journal of the American Chemical Society · 2021Review
- Selective Prebiotic Synthesis of α-Threofuranosyl Cytidine by Photochemical Anomerization.Angewandte Chemie (International ed. in English) · 2021Article
- Coenzymes and Their Role in the Evolution of Life.Angewandte Chemie (International ed. in English) · 2021Review
- Nucleobase Pair-Metal Dimer/Dinuclear Metal Cation Interaction: A Theoretical Study.ACS omega · 2020Article
- Article
- A Model for the Emergence of RNA from a Prebiotically Plausible Mixture of Ribonucleotides, Arabinonucleotides, and 2'-Deoxynucleotides.Journal of the American Chemical Society · 2020Article
- Effect of UV Radiation on Fluorescent RNA Aptamers' Functional and Templating Ability.Chembiochem : a European journal of chemical biology · 2019Article
- How Small Heterocycles Make a Reaction Network of Amino Acids and Nucleotides Efficient in Water.Angewandte Chemie (International ed. in English) · 2019Review
- UV photostability of three 2-aminoazoles with key roles in prebiotic chemistry on the early earth.Chemical communications (Cambridge, England) · 2019Article
- Article
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Authors and funding
8 authors at 4 institutions in 4 countries.
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Abstract
Prebiotic nucleotide synthesis is crucial to understanding the origins of life on Earth. There are numerous candidates for life's first nucleic acid, however, currently no prebiotic method to selectively and concurrently synthesise the canonical Watson-Crick base-pairing pyrimidine (C, U) and purine (A, G) nucleosides exists for any genetic polymer. Here, we demonstrate the divergent prebiotic synthesis of arabinonucleic acid (ANA) nucleosides. The complete set of canonical nucleosides is delivered from one reaction sequence, with regiospecific glycosidation and complete furanosyl selectivity. We observe photochemical 8-mercaptopurine reduction is efficient for the canonical purines (A, G), but not the non-canonical purine inosine (I). Our results demonstrate that synthesis of ANA may have been facile under conditions that comply with plausible geochemical environments on early Earth and, given that ANA is capable of encoding RNA/DNA compatible information and evolving to yield catalytic ANA-zymes, ANA may have played a critical role during the origins of life.
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