Evidence map›Paper›PMID 30287745›Full record

ArticleInternational journal of molecular sciences2018

A Disposable Photovoltaic Patch Controlling Cellular Microenvironment for Wound Healing.

Hyeon-Ki Jang, Jin Young Oh, Gun-Jae Jeong, Tae-Jin Lee, Gwang-Bum Im, Ju-Ro Lee, Jeong-Kee Yoon, Dong-Ik Kim, Byung-Soo Kim, Suk Ho Bhang and 1 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Come together: On-chip bioelectric wound closure.Biosensors & bioelectronics · 2021
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Hyeon-Ki JangResearch Institute for Convergence of Basic Sciences, Hanyang University, Seoul 04763, Korea. alwayshk@hanyang.ac.kr.
Jin Young OhDepartment of Chemical Engineering, Kyung Hee University, Yongin 17104, Korea. jyoh@khu.ac.kr.ORCID 0000-0003-2260-9960
Gun-Jae JeongDivision of Vascular Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea. jgj814@skku.edu.
Tae-Jin LeeSchool of Chemical Engineering, Sungkyunkwan University, Suwon 16419, Korea. leetj@skku.edu.ORCID 0000-0001-6091-542X
Gwang-Bum ImSchool of Chemical Engineering, Sungkyunkwan University, Suwon 16419, Korea. lki1005@skku.edu.
Ju-Ro LeeSchool of Chemical and Biological Engineering, Seoul National University, Seoul 08826, Korea. ljr0518@snu.ac.kr.
Jeong-Kee YoonSchool of Chemical and Biological Engineering, Seoul National University, Seoul 08826, Korea. yoonjk87@snu.ac.kr.
Dong-Ik KimDivision of Vascular Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea. dikim@skku.edu.
Byung-Soo KimSchool of Chemical and Biological Engineering, Seoul National University, Seoul 08826, Korea. byungskim@snu.ac.kr.
Suk Ho BhangSchool of Chemical Engineering, Sungkyunkwan University, Suwon 16419, Korea. sukhobhang@skku.edu.
Tae Il LeeDepartment of BioNano Technology, Gachon University, Seongnam 13120, Korea. t2.lee77@gachon.ac.kr.
Gachon University · KRSeoul National University · KRHanyang University · KRKyung Hee University · KRSamsung Medical Center · KR

Funding

the Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by the Ministry of Science & ICT 2018M3A9E2022954the Korea Health Technology R&D Project grant HI17C1728the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP) NRF-2015R1C1A1A01055224 and NRF-2010-0027955
6 · The paper itself

Abstract

Electrical stimulation (ES) is known to affect the wound healing process by modulating skin cell behaviors. However, the conventional clinical devices that can generate ES for promoting wound healing require patient hospitalization due to large-scale of the extracorporeal devices. Herein, we introduce a disposable photovoltaic patch that can be applied to skin wound sites to control cellular microenvironment for promoting wound healing by generating ES. In vitro experiment results show that exogenous ES could enhance cell migration, proliferation, expression of extracellular matrix proteins, and myoblast differentiation of fibroblasts which are critical for wound healing. Our disposable photovoltaic patches were attached to the back of skin wound induced mice. Our patch successfully provided ES, generated by photovoltaic energy harvested from the organic solar cell under visible light illumination. In vivo experiment results show that the patch promoted cutaneous wound healing via enhanced host-inductive cell proliferation, cytokine secretion, and protein synthesis which is critical for wound healing process. Unlike the current treatments for wound healing that engage passive healing processes and often are unsuccessful, our wearable photovoltaic patch can stimulate regenerative activities of endogenous cells and actively contribute to the wound healing processes.

Indexed as

Cellular MicroenvironmentWound HealingAnimalsCell LineCytokinesElectric Stimulation TherapyExtracellular MatrixFemaleHumansKeratinocytesMicePhototherapyCytokinescellular microenvironment controlcutaneous woundelectrical stimulationorganic photovoltaic

Identifiers

PMID30287745
PMCPMC6213857
OpenAlexW2894867327

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.