Evidence map›Paper›PMID 30287474›Full record

ArticleGenetics2018

Endoplasmic Reticulum Homeostasis Is Modulated by the Forkhead Transcription Factor FKH-9 During Infection of

Erik J Tillman, Claire E Richardson, Douglas J Cattie, Kirthi C Reddy, Nicolas J Lehrbach, Rita Droste, Gary Ruvkun, Dennis H Kim

Open access · bronzeAbstract read
In one paragraph

Article in Genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.3field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Genome-wide characterization of theFrontiers in plant science · 2026
    Article
  3. Review
  4. Article
  5. Unzipping the defense: a comprehensive review on bZIP transcription factors inFrontiers in cellular and infection microbiology · 2025
    Review
  6. Article
  7. Article
  8. Article
  9. Ubiquitin-related processes and innate immunity in C. elegans.Cellular and molecular life sciences : CMLS · 2021
    Review
  10. Innate immunity in C. elegans.Current topics in developmental biology · 2021
    Review
  11. A cullin-RING ubiquitin ligase promotes thermotolerance as part of the intracellular pathogen response inProceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Erik J TillmanDepartment of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139.ORCID 0000-0003-3599-0297
Claire E RichardsonDepartment of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139.
Douglas J CattieDepartment of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139.
Kirthi C ReddyDepartment of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139.
Nicolas J LehrbachDepartment of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts.
Rita DrosteDepartment of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139.
Gary RuvkunDepartment of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts.
Dennis H KimDepartment of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 dhkim@mit.edu.
Massachusetts Institute of Technology · USHarvard University · USMassachusetts General Hospital · US

Funding

PRE-DOCTORAL TRAINING IN THE BIOLOGICAL SCIENCEST32GM007287 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BELL, STEPHEN P., KEATING, AMY E · 1985 to 2019
$40.8M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
Molecular Genetics of Innate Immunity in C. elegansR01GM084477 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI KIM, DENNIS H · 2007 to 2020
$4.6M
NIGMS NIH HHS R01 GM084477NIGMS NIH HHS T32 GM007287NIH HHS P40 OD010440
6 · The paper itself

Abstract

Animals have evolved critical mechanisms to maintain cellular and organismal proteostasis during development, disease, and exposure to environmental stressors. The Unfolded Protein Response (UPR) is a conserved pathway that senses and responds to the accumulation of misfolded proteins in the endoplasmic reticulum (ER) lumen. We have previously demonstrated that the IRE-1-XBP-1 branch of the UPR is required to maintain

Indexed as

AnimalsBortezomibCaenorhabditis elegansCaenorhabditis elegans ProteinsCarrier ProteinsEndoplasmic ReticulumEndoplasmic Reticulum StressForkhead Transcription FactorsGene Expression Regulation, DevelopmentalHomeostasisHost Cell Factor C1Immune SystemLarvaMutationProtein Serine-Threonine KinasesTunicamycinBortezomibCaenorhabditis elegans ProteinsCarrier Proteinsfkh-9 protein, C elegansForkhead Transcription Factorshcf-1 protein, C elegansHost Cell Factor C1IRE-1 protein, C elegansProtein Serine-Threonine KinasesTunicamycinXBP-1 protein, C elegansCaenorhabditis elegansendoplasmic reticulum stressinnate immunityproteasomeUnfolded Protein ResponseWormBase

Identifiers

PMID30287474
PMCPMC6283152
OpenAlexW2895143001

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.