ArticleAJNR. American journal of neuroradiology2018
Impact of Ischemic Lesion Location on the mRS Score in Patients with Ischemic Stroke: A Voxel-Based Approach.
Article in AJNR. American journal of neuroradiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
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Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Aspiration versus stent retriever for posterior circulation stroke: A meta-analysis.CNS neuroscience & therapeutics · 2023Pooled it
- Pooled it
- Cortical Thickness of Brain Areas Beyond Stroke Lesions and Sensory-Motor Recovery: A Systematic Review.Frontiers in neuroscience · 2021Pooled it
- Is early thrombectomy of proximal middle cerebral artery occlusion to salvage internal capsule associated with improved clinical outcomes?Frontiers in stroke · 2026Article
- Evaluating the Relationship Between Motor and Cognitive Impairment and Lesion Size and Location Post-Stroke Using CT Scans.IEEE ... International Conference on Rehabilitation Robotics : [proceedings] · 2025Article
- Article
- The challenge of long-term stroke outcome prediction and how statistical correlates do not imply predictive value.Brain communications · 2025Article
- Connectomic stroke lesion measures provide no benefit over basic spatial lesion features in the prognosis of global stroke outcome measures.Brain communications · 2025Article
- Spatial normalization for voxel-based lesion symptom mapping: impact of registration approaches.Frontiers in neuroscience · 2024Article
- Ischemic stroke outcome prediction with diversity features from whole brain tissue using deep learning network.Frontiers in neurology · 2024Article
- From Admission to Discharge: Predicting National Institutes of Health Stroke Scale Progression in Stroke Patients Using Biomarkers and Explainable Machine Learning.Journal of personalized medicine · 2023Article
- Subcortical infarcts on admission CTP predict poor outcome despite excellent reperfusion in delayed time windows.Neuroradiology · 2023Article
- Microstructural Gray Matter Integrity Deteriorates After an Ischemic Stroke and Is Associated with Processing Speed.Translational stroke research · 2023Article
- Evaluation of Blood Biomarkers and Parameters for the Prediction of Stroke Survivors' Functional Outcome upon Discharge Utilizing Explainable Machine Learning.Diagnostics (Basel, Switzerland) · 2023Article
- Smaller baseline subcortical infarct volume predicts good outcomes in patients with a large core in early acute ischemic stroke after endovascular treatment.Frontiers in neuroscience · 2023Article
- Stroke population-specific neuroanatomical CT-MRI brain atlas.Neuroradiology · 2022Article
- Mechanical thrombectomy for acute posterior cerebral artery stroke; Feasibility and predictors of outcome.Neuroradiology · 2022Article
- Role of S100B Serum Concentration as a Surrogate Outcome Parameter After Mechanical Thrombectomy.Neurology · 2021Article
- Early Thrombectomy Protects the Internal Capsule in Patients With Proximal Middle Cerebral Artery Occlusion.Stroke · 2021Observational
- Exploring the predictive value of lesion topology on motor function outcomes in a porcine ischemic stroke model.Scientific reports · 2021Article
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposePrevious studies indicated that ischemic lesion volume might be a useful surrogate marker for functional outcome in ischemic stroke but should be considered in the context of lesion location. In contrast to previous studies using the ROI approach, which has several drawbacks, the present study aimed to measure the impact of ischemic lesion location on functional outcome using a more precise voxelwise approach. MATERIALS AND
methodsDatasets of patients with acute ischemic strokes from the Multicenter Randomized Clinical Trial of Endovascular Therapy for Acute Ischemic Stroke in the Netherlands (MR CLEAN) were used. Primary outcome was functional outcome as assessed by the modified Rankin Scale 3 months after stroke. Ischemic lesion volume was determined on CT scans 3-9 days after stroke. Voxel-based lesion-symptom mapping techniques, including covariates that are known to be associated with functional outcome, were used to determine the impact of ischemic lesion location for outcome.
resultsOf the 500 patients in the MR CLEAN trial, 216 were included for analysis. The mean age was 63 years. Lesion-symptom mapping with inclusion of covariates revealed that especially left-hemispheric lesions in the deep periventricular white matter and adjacent internal capsule showed a great influence on functional outcome.
conclusionsOur study confirms that infarct location has an important impact on functional outcome of patients with stroke and should be considered in prediction models. After we adjusted for covariates, the left-hemispheric corticosubcortical fiber tracts seemed to be of higher functional importance compared with cortical lesions.
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