ArticleOsteoarthritis and cartilage2019
A graphic user interface for the evaluation of knee osteoarthritis (GEKO): an open-source tool for histological grading.
Article in Osteoarthritis and cartilage, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- A single intra-articular injection of IDO-Gal3 shifts synovial fluid metabolic profiles for up to six weeks in male rats with knee instability.Biochimie · 2026Article
- Review
- Post-traumatic osteoarthritis in aged rodents is associated with brain changes that correlate with joint remodeling.The journal of pain · 2026Article
- Comorbid hypertension and osteoarthritis exacerbates joint remodeling and gait compensations in female rats with milder effects observed in males.Osteoarthritis and cartilage open · 2025Article
- Using deep-learning based segmentation to enable spatial evaluation of knee osteoarthritis (SEKO) in rodent models.Osteoarthritis and cartilage · 2025Article
- Vagotomy accelerates the onset of symptoms during early disease progression and worsens joint-level pathogenesis in a male rat model of chronic knee osteoarthritis.Osteoarthritis and cartilage open · 2024Article
- Intra-articular delivery of an indoleamine 2,3-dioxygenase galectin-3 fusion protein for osteoarthritis treatment in male Lewis rats.Arthritis research & therapy · 2023Article
- Intra-Articular Delivery of an Indoleamine 2,3-Dioxygenase Galectin-3 Fusion Protein for Osteoarthritis Treatment in Male Lewis Rats.Research square · 2023Article
- Hypertension contributes to exacerbated osteoarthritis pathophysiology in rats in a sex-dependent manner.Arthritis research & therapy · 2023Article
- Age alters gait compensations following meniscal injury in male rats.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2022Article
- Measures of cardiovascular function suggest autonomic nervous system dysregulation after surgical induction of joint injury in the male Lewis rat.Osteoarthritis and cartilage · 2022Article
- Sodium alginate microencapsulation of human mesenchymal stromal cells modulates paracrine signaling response and enhances efficacy for treatment of established osteoarthritis.Acta biomaterialia · 2022Article
- Effects of cartilage-targeting moieties on nanoparticle biodistribution in healthy and osteoarthritic joints.Acta biomaterialia · 2020Article
- The effects of age on the severity of joint damage and intra-articular inflammation following a simulated medial meniscus injury in 3, 6, and 9 month old male rats.Connective tissue research · 2020Article
- Manganese dioxide nanoparticles protect cartilage from inflammation-induced oxidative stress.Biomaterials · 2019Article
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4 authors.
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Abstract
objectiveIn osteoarthritis (OA) models, histology is commonly used to evaluate the severity of joint damage. Unfortunately, semi-quantitative histological grading systems include some level of subjectivity, and quantitative grading systems can be tedious to implement. The objective of this work is to introduce an open source, graphic user interface (GUI) for quantitative grading of knee OA.
methodsInspired by the 2010 OARSI histopathology recommendations for the rat, our laboratory has developed a GUI for the evaluation of knee OA, nicknamed GEKO. In this work, descriptions of the quantitative measures acquired by GEKO are presented and measured in 42 histological images from a rat knee OA model. Using these images, across-session and within-session reproducibility for individual graders is evaluated, and inter-grader reliability across different levels of OA severity is also assessed.
resultsGEKO allowed histological images to be quantitatively scored in less than 1 min per image. In addition, intra-class coefficients (ICCs) were largely above 0.8 for across-session reproducibility, within-session reproducibility, and inter-grader reliability. These data indicate GEKO aided in the reproducibility and repeatability of quantitative OA grading across graders and grading sessions.
conclusionsOur data demonstrate GEKO is a reliable and efficient method to calculate quantitative histological measures of knee OA in a rat model. GEKO reduced quantitative grading times relative to manual grading systems and allowed grader reproducibility and repeatability to be easily assessed within a grading session and across time. Moreover, GEKO is being provided as a free, open-source tool for the OA research community.
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