Evidence map›Paper›PMID 30287307›Full record

ArticleNeuroscience letters2018

Does acute heat stress differentially-modulate expression of ionotropic neurotransmitter receptors in the RVLM of young and aged F344 rats?

Hitesh N Pawar, Sivasai Balivada, Michael J Kenney

Abstract read
In one paragraph

Article in Neuroscience letters, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Subregional differences in GABAThe Journal of comparative neurology · 2020
    Article
  3. Link Prediction in Multipartite Graphs With Application to Drug Repositioning Studies.IEEE transactions on computational biology and bioinformatics
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Hitesh N PawarDepartment of Biological Sciences, College of Science, University of Texas at El Paso, El Paso, TX 79968, USA. Electronic address: hnpawar@utep.edu.
Sivasai BalivadaDepartment of Biological Sciences, College of Science, University of Texas at El Paso, El Paso, TX 79968, USA.
Michael J KenneyDepartment of Biological Sciences, College of Science, University of Texas at El Paso, El Paso, TX 79968, USA.
The University of Texas at El Paso · US

Funding

TCCG12MD007592 · NIMHD · UNIVERSITY OF TEXAS EL PASO · PI KIRKEN, ROBERT A. · 2012 to 2018
$19.4M
Sympathetic Neural Regulation and Aging: Medullary Mechanisms and StrategiesR01AG041948 · NIA · UNIVERSITY OF TEXAS EL PASO · PI KENNEY, MICHAEL J · 2012 to 2015
$1.5M
NIA NIH HHS R01 AG041948NIMHD NIH HHS G12 MD007592
6 · The paper itself

Abstract

The rostral ventral lateral medulla (RVLM) is a brainstem area that plays a role in regulating numerous physiological systems, especially their responsiveness to acute stress. Aging affects the responsiveness of RVLM neural circuits to acute stress. Based on the relationship between ionotropic neurotransmitter receptors in the RVLM and the physiological functions mediated via activation of these receptors, we hypothesized that in response to acute heat stress the expression of ionotropic neurotransmitter receptors in the RVLM of aged rats would be characterized by upregulation of inhibitory subunits and downregulation of excitatory subunits. The goal of the present study was to determine the effect of acute heating on the gene expression profile of RVLM inhibitory (GABA

Indexed as

AnimalsBlood PressureBrain StemHeat-Shock ResponseHot TemperatureMaleMedulla OblongataNeurotransmitter AgentsRats, Inbred F344Receptors, NeurotransmitterSympathetic Nervous SystemNeurotransmitter AgentsReceptors, NeurotransmitterAgingGene expressionHeat stressNeurotransmitter receptor subunitsRVLM

Identifiers

PMID30287307
PMCPMC6231992
OpenAlexW2894695827

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.